Platelet Rich Plasma Versus Placebo for the Treatment of Greater Trochanteric Pain Syndrome (HiPPO Trial)

Launched by NORTHUMBRIA HEALTHCARE NHS FOUNDATION TRUST · Mar 20, 2018

Keywords

ClinConnect Summary

1. What is the problem being addressed? Greater trochanteric pain syndrome (GTPS), also known as trochanteric bursitis, is a painful condition characterised by pain around the greater trochanter usually affecting middle aged women (1). It was first described, as trochanteric bursitis in 1958 (2). Further details on the clinical symptoms published in 1978 as pain over the greater trochanter on walking, squatting or climbing stairs and pain on lying on the affected side or when crossing one's legs (3). Little described tenderness over the greater trochanter over the insertion of the gluteus t...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Over 18 years of age
• • 2. Symptoms consistent with GTPS present for at least 6 months
• • 3. Radiological diagnosis of GTPS using MRI, or ultrasound scan if MRI contraindicated
• • 4. Failed conservative management in any other care setting
• • 5. Patient is willing and able to provide written informed consent.
• Exclusion Criteria:
• • 1. Lacks capacity to provide consent
• • 2. Has hip joint osteoarthritis requiring treatment on a plain radiograph
• • 3. Presence of confounding pathologies of the hip MRI
• • 4. Any extensive surgery or deformity of the hip on X-ray.
• • 5. Presence of systemic disorders -coagulopathy, active infection, immune system disorders, peripheral neuropathy, malignancy, unresolved fractures.
• • 6. Had any surgical treatment specifically targeted at GTPS e.g. bursectomy/Ilio-tibial band lengthening
• • 7. Pregnancy
• • 8. Anti-coagulant therapy eg warfarin, rivaroxaban, apixaban, dabigatran
• • 9. Haemaglobin \<10g/dL or platelets \< 150,000/ul
• • 10. Unable to safely stop anti-platelet/NSAID medications eg. Recent cardiac stenting
• • 11. Has lumbar-sacral spine pathology or a recent history of acute hip trauma
• • 12. Has a recent history of acute sciatica
• • 13. Is not able to attend or comply with treatment or follow-up scheduling
• • 14. Participates in any other clinical trial