Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

Launched by MASSACHUSETTS GENERAL HOSPITAL · Mar 27, 2018

Keywords

ClinConnect Summary

This clinical trial, called the Biomechanical Precision Medicine Registry, is focused on understanding different types of heart failure and how they progress over time. Researchers will collect a variety of information including medical history, blood tests, and imaging studies to learn more about heart failure and its causes. The goal is to find the right treatments for each patient, minimizing side effects and improving care.

To participate in this study, you need to be at least 18 years old and have symptoms of heart failure, confirmed by specific medical tests. The trial is open to all genders and is currently recruiting participants. If you join, you can expect to undergo various assessments and tests over time, which will help researchers gather important data to improve how heart failure is treated in the future. However, if you are on dialysis for severe kidney disease, you would not be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion criteria for patients with HF:
• • 18 years and older
• * History of clinical symptoms consistent with HF and at least one of the following supporting evidence of HF:
• • NT-proBNP \> 125 pg/mL
• • BNP \> 35 pg/mL
• • Capillary wedge pressure ≥ 15 mmHg on right heart catheterization or CI \<2.8 L/min/m2
• • LVEDP ≥ 15 mmHg
• • Radiographic evidence of pulmonary edema
• • Improvement in symptoms with diuretic initiation of increase
• • CPET evidence of cardiac etiology of symptoms
• • HFpEF: LVEF ≥ 50% HFrEF: LVEF \<50%
• Exclusion criteria (for all patients, including both those with HFpEF and HFrEF):
• • - End stage renal disease on dialysis