Ischemic Conditioning During Air tRansport Save penUmbral Tissue

Launched by ENRIQUE LEIRA · Mar 21, 2018

Keywords

ClinConnect Summary

This clinical trial is looking at a new treatment approach for patients experiencing an acute stroke caused by a blockage in a large blood vessel. The study aims to see if a special device, called the Doctormate, can help protect the brain tissue during air transport to a hospital that can provide more advanced treatment. This method is known as remote limb ischemic conditioning (RLIC), which involves temporarily restricting blood flow to a limb to improve blood flow to the brain.

To be eligible for this trial, participants need to be between 18 and 80 years old and show symptoms of a stroke, such as trouble speaking or seeing. They should also be assessed for a specific medication called rtPA, which helps dissolve blood clots, and able to provide consent for participation. If you or a loved one qualifies and decides to participate, you can expect to be safely monitored during air transport while receiving this innovative treatment aimed at preserving brain health during this critical time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 and ≤ 80 years
• • 2. Suspected acute ischemic stroke with symptoms suggestive of large vessel occlusion (aphasia, agnosia, neglect, visual field cut, and gaze preference).
• • 3. Patient screened for rtPA, and rtPA administered if eligible
• • 4. Subject or legally authorized representative able to provide consent at the time of the assessment
• • 5. NIHSS 6-20
• Exclusion Criteria:
• • 1. Any intracranial hemorrhage (parenchymal, subarachnoid, subdural, epidural) on CT scan at the community hospital
• • 2. History of upper or lower extremity ischemia, known subclavian, brachial artery, iliac or femoral artery stenosis, subclavian steal syndrome, any upper or lower extremity soft tissue, orthopedic or vascular injury, or mastectomy or other procedure that may contraindicate taking blood pressure or having a cuff on the arm or leg for the conditioning treatment
• • 3. History of diabetes mellitus
• • 4. Enrollment in another clinical trial
• • 5. Patient incarcerated
• • 6. Pregnancy. Patients ages 18-55 will need to have a negative urine or blood based pregnancy test.
• • 7. Agitation deemed unsafe for ischemic preconditioning testing.
• • 8. Arteriovenous fistula in upper limb