The Role of Circadian Clock Proteins in Innate and Adaptive Immunity

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Mar 27, 2018

Keywords

ClinConnect Summary

This clinical trial is investigating how exposure to a special type of bright blue light might help improve the body’s response to infections and surgeries, such as pneumonia and infections requiring surgery. Researchers want to see if this blue light can reduce inflammation and organ problems in patients undergoing treatment for conditions like pneumonia or certain types of infections in the abdomen or joints. Participants will be divided into two groups: one will receive the blue light treatment for 12 hours a day for three days, while the other group will have standard white fluorescent light.

To participate in this study, individuals must be between 18 and 65 years old and have a specific infection that requires hospital care, such as surgery for an infected joint or treatment for pneumonia. Participants will be monitored for changes in their body’s inflammatory response through blood tests and other health checks. It’s important to note that people with certain conditions, like recent infections or specific eye problems, will not be eligible for the trial. This study aims to find new ways to improve patient care and outcomes after serious medical treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • greater than or equal to 18 years of age and less than or equal to 65 years of age
• • one of the following diagnoses requiring inpatient hospital care
• • 1. an operation for intraabdominal infection
• • 2. an operation for necrotizing soft tissue infection
• • 3. an operation for an infected joint
• • 4. medical treatment of pneumonia.
• Exclusion Criteria:
• • traumatic brain injury
• • blindness
• • immunocompromised or immunosuppressed state
• • infection requiring treatment in preceding 30 days
• • blindness
• • SARS-CoV-2