Coronary Atherosclerosis T1-Weighted Characterization (CATCH)

Launched by CEDARS-SINAI MEDICAL CENTER · Apr 19, 2018

Keywords

ClinConnect Summary

The Coronary Atherosclerosis T1-Weighted Characterization (CATCH) trial is researching a new MRI technique aimed at improving how doctors evaluate coronary atherosclerosis, which is the buildup of fatty deposits in the arteries of the heart. This new method is designed to provide clearer images while making the scanning process easier and quicker than traditional methods. The trial is currently recruiting participants, and they are looking for both healthy volunteers and patients who are medically stable and over 18 years old.

To be eligible, healthy volunteers should have a body mass index (BMI) under 30 and no history of heart disease. Patients should not have been diagnosed with coronary artery disease or had procedures like stenting or bypass surgery. Participants can expect to undergo MRI scans and may need to follow specific instructions to ensure their safety during the process. It's important to note that people with certain medical devices, severe allergies to animal dander, or kidney issues may not qualify for the study. This trial could significantly advance how heart health is monitored and managed in the future.

Gender

ALL

Eligibility criteria

• Inclusion:
• • Healthy Volunteers: male or female ≥ 18 years of age with a BMI\<30, with no history of cardiovascular disease
• • Patients: Medically stable, male or female ≥ 18 years of age who is have not suspected of having or has been diagnosed with coronary artery disease and undergone stenting or bypass surgery
• Exclusion:
• • Contraindications to MR imaging including mechanically, magnetically, or electrically activated implants, ferromagnetic implants and ferromagnetic foreign bodies, pregnancy.
• • Inability to tolerate MR imaging secondary to an inability to hold breath for a short time or have claustrophobia.
• • Non-compliant with visit instructions, including following procedure instructions
• • Severe allergy to animal dander or animal-instigated asthma
• • Specific to gadolinium-based contrast agents: Renal function test does not meet CSMC standard of care MRI contrast protocol requirements (GFR \<45ml/min) or previous allergic reaction to gadolinium-based contrast agents.\*
• • Volunteers who have had four or more prior previous gadolinium contrast scan