Effectiveness of Metronidazole Gel and Mobile SMS Reminders on Gingivitis in Orthodontic Patients
Launched by AGA KHAN UNIVERSITY · Apr 25, 2018
Trial Information
Current as of June 26, 2025
Completed
Keywords
ClinConnect Summary
Gingivitis: It is defined as the inflammation of the gingiva in the absence of clinical attachment loss.
Six standard sites on incisors, canines and premolars have been used in this study as study sites as described by Gettinger et al. The investigators will not include banded first molars because the banding itself will lead to a compromise in periodontal conditions. The study sites will be six proximal-buccal line angles on the following teeth: right maxillary second premolar, mesiobuccal line angle; right maxillary canine, distobuccal line angle; left maxillary central incisor, distolab...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients undergoing orthodontic treatment with fixed appliance since 6 months
- • Patients with all bonded teeth mesial to the first molars and not adjacent to a banded tooth
- • Systematically healthy patient with no co-morbid such as rheumatic fever, blood dyscrasias, congenital heart disease or diabetes mellitus
- • Subjects with gingivitis as assessed by bleeding index (score =2), orthodontic plaque index (score ≥ 2) and gingival index (score ≥ 2) as assessed by Williams Probe
- • All patients who sign the inform consent will be included in the study
- Exclusion Criteria:
- • Subjects with clinical attachment loss of greater than 2 mm on two sites
- • Pregnant or lactating females
- • Subjects with removal or fixed dental prosthesis, teeth with banding used for attachment
- • History of surgical or nonsurgical periodontal therapy in the last 6 months
- • Use of antibiotic or anti-inflammatory in the last 30 days confirmed by patient's history
- • Habit of smoking or use of smokeless tobacco
- • Allergic to Metronidazole according to patient history
About Aga Khan University
Aga Khan University (AKU) is a distinguished institution dedicated to improving health and education across developing regions. Established in 1983, AKU is recognized for its commitment to research excellence, particularly in clinical trials that address pressing health issues in diverse populations. With a focus on advancing medical knowledge and practice, AKU's clinical trial initiatives are designed to foster innovative solutions and enhance patient care. The university collaborates with various local and international partners, leveraging its multidisciplinary expertise to conduct rigorous research that informs public health policy and improves health outcomes in communities served by its facilities.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Karachi, Sindh, Pakistan
Patients applied
Trial Officials
Mubassar Fida, BDS, FCPS
Principal Investigator
Consultant
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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