Autonomic Control of the Circulation and VDR

Launched by MILTON S. HERSHEY MEDICAL CENTER · Apr 19, 2018

Keywords

ClinConnect Summary

This clinical trial is studying how a specific reflex in our bodies, called the venous distension reflex (VDR), affects blood circulation and blood pressure. Researchers want to understand how a medication called ketorolac, which is a type of pain relief medicine, influences this reflex when they apply pressure to veins in the arms or legs. To do this, they will use advanced MRI technology to look at how veins change in size during this process, with and without the medication.

To participate in this trial, you need to be between 21 and 35 years old and weigh more than 50 kg. You should also be healthy, meaning you don’t have any chronic diseases or take certain medications that might affect your heart or nervous system. If you qualify, you can expect to undergo some tests and receive either the ketorolac or a placebo (a harmless substance with no active medicine) during the study. It’s important to note that if you take any anti-inflammatory drugs, you may need to reschedule your visit. This study aims to help us better understand how our bodies regulate blood flow and blood pressure, which could lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • Are capable of giving informed consent
• • Are any race or ethnicity
• • Are fluent in written and spoken English
• • Have a satisfactory history and physical exam to meet inclusion/exclusion criteria
• • Are free of acute or chronic medical conditions
• • Are 21 - 35 years of age (inclusive)
• • Weigh over 50 kg
• • Exclusion Criteria
• • Are less than 21 or over 35 years of age
• • Are Pregnant or nursing women
• • Are prisoners or institutionalized individuals or unable to consent
• • Any chronic diseases (hypertension, heart, lung, neuromuscular disease, kidney disease, diabetes or cancer).
• • Are taking medications that may affect their cardiovascular or nervous system
• • Has taken an NSAID within 48 hours of any visit (visit will need to be rescheduled)
• • Has never taken NSAIDs and therefore would not know if they are allergic to it
• • Have a supine BP \>140/90 mmHg
• • Have known allergy to ibuprofen-like drugs (NSAIDS) or aspirin
• • Have history of asthma or nasal polyps
• • Have history of GI bleeding or ulcers
• • Subjects with ferromagnetic metal implants
• • Subjects who are claustrophobic