Post-Operative Analgesic Effects of Local Wound Infiltration With Ketorolac After Inguinal Herniorrhaphy

Launched by MAHIDOL UNIVERSITY · May 22, 2018

Keywords

ClinConnect Summary

The study design is a prospective randomized, double-blind, controlled trial of patients who are undergoing elective unilateral inguinal herniorrhaphy at Ramathibodi Hospital during the period 1 July 2018 - 30 June 2020 The primary outcome is to study the effectiveness of Ketorolac injections in pain relief after herniorrhaphy surgery and the secondary outcome is to study the adverse effects and complications after injection of Ketorolac: anaphylactic shock, abnormal bleeding at surgical wound, gastrointestinal bleeding and acute kidney injury.

After approval by the ethics committee, patie...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18 to 75 years old undergoing elective unilateral inguinal herniorrhaphy at Ramathibodi hospital
• • Patients who are ASA classification 1-2
• • Patients who had normal liver function test : AST 5-34 U/L , ALT 0-55 U/L, ALP 40-150 U/L ,TB0.2-1.2 mg/dL ,DB 0.0-0.5 mg/dL
• • Patients who are going the operation under general anesthesia
• • Patients who undergoing herniorrhaphy with Lichtenstein Tension-Free Repair technique
• Exclusion Criteria:
• • Patients who had femoral hernia
• • Patients who had history of NSAIDs allergy
• • Patients with history of prior hernorrhaphy
• • Patients who had history of GI bleeding and gastritis
• • Patients who had infection
• • Patients who had history of SLE, HIV, asthma , cardiovascular disease and chronic kidney disease(GFR\<60 ml/min/1.73m2)
• • Patients with end stage disease
• • Patients who are pregnant
• • Patients who reject or withdrawal from research