The Efficacy of Cholesterol-lowering Probiotic Lactobacillus Plantarum LPLDL® in Hypercholesterolemic Adults.

Launched by UNIVERSITY OF ROEHAMPTON · May 25, 2018

Keywords

ClinConnect Summary

The aim of this human volunteer study is to establish the extent of extent of the cholesterol lowering potential of Lactobacillus plantarum ECGC 13110402 in 50 hypercholesterolaemic adults (35-70 years old).

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • males and females from 35 to 70 years of age
• • BMI 18.5 to 29.9 kg/m2
• • total cholesterol (TC) \>6mmol/L.
• Exclusion Criteria:
• • suffering from chronic gastrointestinal complaints (including chronic constipation, diarrhoea or Irritable Bowel Syndrome)
• • diabetes or anaemia
• • requirement to take long-term medications active on the gastrointestinal tract, treatment of cardio-vascular disease, or any other long-term medication
• • high blood cholesterol or use of cholesterol lowering drugs/ functional foods
• • history of drug or alcohol misuse or alcohol consumption exceeding 14 and 21 units/week for females and males respectively
• • those suffering with any allergies to medication or food
• • on weight-reducing diets.
• • Females planning pregnancy within six months from the start of the study, lactating, or have given birth within the preceding six months
• • use of antibiotics within six months preceding the study, participation in any probiotic, prebiotic or laxative study or intake of an experimental drug four weeks prior to the study start.
• • Individuals exercising \> 16 744 kJ per week