Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric AKI

Launched by CHILDREN'S HOSPITAL MEDICAL CENTER, CINCINNATI · May 29, 2018

Keywords

ClinConnect Summary

In the pediatric population, acute kidney injury (AKI) is commonly observed in critically ill patients. At this time, there are no standardized care pathways that begin at identifying patients at risk for developing AKI and progress through to early recognition and treatment. Through previous work, the investigators have developed, tested, and integrated an AKI risk-stratification/clinical recognition tool (RAI) and a urine biomarker (NGAL) to try to identify patients at risk vs. not at-risk for developing AKI. However, these factors alone have yet to be integrated into clinical decision su...

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Eligibility criteria

• Inclusion Criteria:
• • Admitted to the Pediatric Intensive Care Unit (PICU)
• • Renal Angina Index (RAI) greater than or equal to 8
• • Urine NGAL greater than or equal to 150 ng/mL
• • Indwelling urinary catheter
• Exclusion Criteria:
• • Evidence of volume depletion
• • Baseline Chronic Kidney Disease (CKD) Stage IV or V (estimated GFR \<60 mL/min/1.73m2)
• • History of kidney transplantation
• • Active DNR order or clinical team is not committed to escalating medical care
• • Known history of allergic reaction to furosemide (only for FST)