Genetic Education in BRCA Families

Launched by GEORGETOWN UNIVERSITY · May 22, 2018

Keywords

ClinConnect Summary

Women who carry a pathogenic BRCA variant (PV) have a lifetime breast cancer risk of 55-70% and a lifetime ovarian cancer risk of 16-45%. Men with a PV are at increased risk for prostate, pancreatic and breast cancer. BRCA testing typically begins with a family member (proband) who is affected with cancer. If a PV is identified, probands are encouraged to communicate this test result with at risk relatives. Unaffected first- and second-degree relatives (FSDR), who are at 50% and 25% risk for carrying the PV, may then pursue genetic counseling and testing for the specific variant identified ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • A first- (sibling, adult offspring) or second-degree (aunt/uncle, niece/nephew if at-risk parent is deceased) biological relative of an individual with a recently identified BRCA1 or BRCA2 mutation
• Exclusion Criteria:
• • Personal diagnosis of metastatic cancer
• • Prior genetic testing for hereditary breast/ovarian cancer
• • Have one or more children who have tested positive for a BRCA1 or BRCA2 mutation
• • Cannot participate in or understand English
• • Cannot provide meaningful informed consent