Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial)
Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · May 24, 2018
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The INDOMAP Trial is studying whether a medication called indomethacin can help treat acute pancreatitis (AP), which is a painful inflammation of the pancreas. The trial aims to find out if giving this medicine early on can lower the risk of serious complications and improve patients' recovery. The researchers are looking for adults aged 18 to 80 who are diagnosed with acute pancreatitis based on specific symptoms and tests, like abdominal pain and elevated enzyme levels in their blood.
If you or someone you know is considering participating in this trial at Peking Union Medical College Hospital, it's important to know that participants will be closely monitored while receiving treatment. However, certain individuals may not be eligible, such as those with kidney problems, active bleeding in the stomach, or those who have recently taken specific medications. This study is currently recruiting participants, and it could provide valuable information about how indomethacin works in treating acute pancreatitis.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- * All patients ages 18-80 years with a diagnosis of AP based on at least 2 of the following criteria:
- • Abdominal pain characteristic of AP
- • Serum amylase and/or lipase ≥ 3 times the upper limit of normal
- • Characteristic findings of AP on abdominal CT scan will be screened for study enrollment.
- Exclusion Criteria:
- • Onset time \>24 hours
- • Presence of renal dysfunction (serum creatinine \> 1.5 \*normal upper limit)
- • Severe liver dysfunction
- • Active peptic ulcer disease or GI bleeding
- • Pregnancy or breast-feeding
- • Hypersensitivity to NSAIDs
- • New-onset, exacerbation or uncontrolled hypertension
- • Presence of serious cardiovascular events, including severe heart failure, myocardial infarction (MI) and stroke
- • Mental disability
- • Malignancy-associated acute pancreatitis
- • Post-ERCP pancreatitis
- • Informed consent not signed
About Peking Union Medical College Hospital
Peking Union Medical College Hospital (PUMCH) is a prestigious medical institution and a leading research facility located in Beijing, China. Affiliated with the Chinese Academy of Medical Sciences, PUMCH is renowned for its commitment to advancing healthcare through innovative clinical research and high-quality patient care. The hospital plays a pivotal role in the development and execution of clinical trials across various medical disciplines, focusing on improving treatment outcomes and enhancing medical knowledge. With a multidisciplinary team of experts and state-of-the-art facilities, PUMCH is dedicated to contributing to global health advancements and fostering collaborations in the medical research community.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Beijing, Beijing, China
Beijing, Beijing, China
Jinhua, Zhejiang, China
Beijing, Beijing, China
Xining, Qinghai, China
Suqian, Jiangsu, China
ürümqi, Xinjiang, China
Nantong, Jiangsu, China
Lishui, Zhejiang, China
Guiyang, Guizhou, China
Baoding, Hebei, China
Harbin, Heilongjiang, China
Dengzhou, Henan, China
Nanyang, Henan, China
Huaian, Jiangsu, China
Wuxi, Jiangsu, China
Chengdu, Sichuan, China
Patients applied
Trial Officials
Dong Wu, M.D.
Study Chair
Peking Union Medical College Hospital
Zhitao Lu, M.D.
Principal Investigator
Baoding Seventh Hospital
Yanfeng Wang, M.D.
Principal Investigator
Liangxiang Hospital
Shanshan Yu, M.D.
Principal Investigator
Guiyang Second People's Hospital
Na Wu, M.D.
Principal Investigator
Dengzhou People's Hospital
Mei Liu, M.D.
Principal Investigator
Affiliated Hospital of Qinghai University
Xiao Fan, M.D.
Principal Investigator
Second People Hospital of Nanyang
Zuoyan Wu, MD
Principal Investigator
Peking University Sixth Hospital
Ruifeng Wang, MD
Principal Investigator
Harbin Medical University
Baofeng Zhu, MD
Principal Investigator
Nantong First People's Hospital
Yan Shi, MD
Principal Investigator
The Second People's Hospital of Huai'an
Ming Sun, MD
Principal Investigator
Suqian People's Hospital
Wei Huang, MD
Principal Investigator
Wuxi Third People's Hospital
Shicheng Zheng, MD
Principal Investigator
West China Longquan Hospital Sichuan University
Jianzhong Yang, MD
Principal Investigator
First Affiliated Hospital of Xinjiang Medical University
Daoyuan Jing, MD
Principal Investigator
Jinhua Municipal Central Hospital
Hong Liu, MD
Principal Investigator
Lishui Municipal Central Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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