Gluten-related Disorders in Familial Mediterranean Fever Patients

Launched by UNIVERSITY OF PALERMO · Jun 19, 2018

Keywords

ClinConnect Summary

It is known that the gluten-containing grains can be responsible for human diseases related to gluten exposure. These forms of gluten intolerance represent a heterogeneous set of conditions, including celiac disease (CD), wheat allergy (WA) and not celiac gluten sensitivity (NCGS), that combined seems to affect about 5-10% of the general population. NCGS is the most recent gluten-related disease. It is characterized by intestinal (i.e. irritable bowel syndrome, bloating, dyspepsia) and extra-intestinal symptoms (i.e. fatigue, headache, numbness, mental confusion) related to the ingestion of...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients, both genders, with age between 18-65 years, affected with FMF, diagnosed according to clinical criteria designed by Livneh et al ("Tel-Hashomer" criteria), self-reporting a relationship between their symptoms (especially gastrointestinal) and gluten assumption, improving on a gluten-free diet and worsen on a gluten containing diet
• • Patients testing negative for celiac disease (anti-tTG and EMA negative, and with biopsy Marsh 0-1) and wheat allergy (serum specific IgE for wheat negative)
• Exclusion Criteria:
• • Subjects diagnosed with celiac disease (positive anti-tTG and/or EMA, and positive histology, with Marsh 2 or above);
• • Subjects diagnosed with wheat allergy (positive serum specific IgE for wheat)
• • Subjects with Inflammatory Bowel Diseases (Crohn's disease or ulcerative colitis)
• • Subjects with Helicobacter pylori infection and other gastrointestinal infection
• • Pregnancy