Effect of Ascorbic Acid Supplementation in Pregnancy on Anemia (AAA)

Launched by FETAL MEDICINE FOUNDATION · Jun 19, 2018

Keywords

ClinConnect Summary

A. Anemia is the most common hematological abnormality during pregnancy and was found to affect 24.1% of pregnant women in a WHO study.2 The most common types of anemia affecting pregnancy are iron-deficiency and acute blood loss. Vitamin C, also known as ascorbic acid, has been well documented to play an active role in the absorption and metabolism of iron from the gut.6 Vitamin C has been used in studies to treat anemic non-pregnant women resulting in significant increases in hemoglobin levels. Similar effects have been found in multiple studies using vitamin C as adjunct treatment for he...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • gestational age at enrollment less than 20 0/7 weeks,
• • singleton gestation,
• • iron deficiency anemia defined as maternal serum ferritin levels less than 15 micrograms/dL, and
• • planned delivery at Miami Valley Hospital.
• Exclusion Criteria:
• • vitamin C use \>150mg/day (typical prenatal vitamin contains 60mg Vitamin C),
• • diabetes (gestational, types 1,2); chronic medical disease;
• • known or discovered hemoglobinopathy (including heterozygous states);
• • known metabolic disease that may contribute to impaired iron absorption (including a history of bariatric surgery, renal disease and an inability to tolerate oral iron);
• • known fetal abnormalities;
• • participation in another interventional trial;
• • illicit drug or alcohol use