Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG)

Launched by NATIONAL UNIVERSITY HOSPITAL, SINGAPORE · Jun 17, 2018

Keywords

ClinConnect Summary

This clinical trial is studying how the body processes a medication called simvastatin after a surgery known as laparoscopic sleeve gastrectomy (LSG), which is often performed to help people with obesity. The main goal is to see if this surgery changes how well simvastatin works in the body. This information is important because simvastatin is commonly used to help lower cholesterol levels, and understanding its effectiveness post-surgery can help doctors provide better care.

To be eligible for the trial, participants need to be at least 21 years old, be scheduled for LSG at the National University Hospital, and already be taking simvastatin. However, people who are pregnant or taking certain other medications that might interfere with simvastatin won’t be able to participate. If you join the study, you can expect to have your medication's effects monitored after your surgery, which will help researchers learn more about how LSG impacts the treatment of obesity and high cholesterol.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Planned for laparoscopic sleeve gastrectomy at National University Hospital
• • Taking statin
• • Aged 21 or above
• Exclusion Criteria:
• • Patient on concomitant treatment with medications/ food/ herbal supplements that may affect the pharmacokinetics of simvastatin: boceprevir, conivaptan, cyclosporine, efavirenz, mitotane, tocilizumab, rifamycin, amiodarone, amlodipine, aprepitant, azithromycin, colchicine, fenofibrate, imatinib, raltegravir, ranolazine, teriflunomide, ticagrelor, fusidic acid, protease inhibitors, telaprevir, telithromycin, gemfibrozil, erythromycin, clarithromycin, carbamazepine, rifampicin, ketoconazole, fluconazole, itraconazole, voriconanzole, diltiazem, verapamil, dexamethasone, prednisolone, phenytoin, ritonavir, indinavir, nelfinavir, bosentan, telithromycin, nefazodone, St John's wort, orlistat, sibutramine and other strong CYP 3A4 inhibitors/ inducers
• • Pregnant ladies