Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
Launched by THE UNIVERSITY OF QUEENSLAND · Jun 18, 2018
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The PHOSPHATE trial is studying the effects of lowering blood phosphate levels in patients with end-stage kidney disease (ESKD). While doctors recommend reducing high phosphate levels to improve health, we don’t yet know how this impacts important outcomes like heart disease, overall health, and even costs for patients. This trial aims to find out if lowering phosphate levels can help reduce the risk of death or heart problems, improve physical well-being, and be more cost-effective compared to keeping phosphate levels higher.
To participate in this trial, you need to be at least 45 years old (or 18 years old with diabetes), have been on dialysis for at least three months, and be taking at least one medication to lower phosphate levels. You should also be able to give your consent to participate. Participants will be monitored to see how lowering phosphate affects their health and well-being. It’s important to know that if you have plans for a kidney transplant soon or have other serious health issues, you may not be eligible for this study.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Age ≥45 years, or Age ≥18 years with diabetes,
- • 2. ESKD on haemodialysis or peritoneal dialysis, for at least 3 months,
- • 3. Currently prescribed at least one phosphate-lowering medication at any dose
- • 4. Able to provide informed consent
- Exclusion Criteria:
- • 1. Elective kidney transplantation scheduled,
- • 2. Concomitant major illness / comorbidity that may result in death in the next 6 months in the view of the treating physician,
- • 3. Participation in an interventional study that is likely to affect serum phosphate concentration.
About The University Of Queensland
The University of Queensland (UQ) is a leading research institution located in Australia, renowned for its commitment to advancing health and medical knowledge through innovative clinical trials. With a strong emphasis on collaboration between academia, industry, and healthcare communities, UQ leverages its extensive resources and expertise to conduct high-quality research aimed at improving patient outcomes. The university's multidisciplinary approach facilitates the exploration of diverse therapeutic areas, ensuring rigorous scientific methodologies and adherence to ethical standards. UQ's dedication to fostering a culture of discovery positions it at the forefront of clinical research, contributing significantly to the global body of medical knowledge.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Wollongong, New South Wales, Australia
Kingston, Ontario, Canada
Vancouver, British Columbia, Canada
Christchurch, , New Zealand
Vancouver, British Columbia, Canada
Bedford Park, South Australia, Australia
Leicester, , United Kingdom
Melbourne, Victoria, Australia
Hastings, , New Zealand
Dunedin, , New Zealand
Ottawa, Ontario, Canada
Heidelberg, Victoria, Australia
Kogarah, New South Wales, Australia
Sherbrooke, Quebec, Canada
Auckland, , New Zealand
Toronto, Ontario, Canada
Kfar Saba, , Israel
London, Ontario, Canada
Brisbane, Queensland, Australia
Montréal, Quebec, Canada
Hamilton, , New Zealand
London, , United Kingdom
Canterbury, Kent, United Kingdom
Southport, Queensland, Australia
Reading, , United Kingdom
Nottingham, , United Kingdom
Ramat Gan, , Israel
Meadowbrook, Queensland, Australia
Saint Leonards, New South Wales, Australia
Cairns, Queensland, Australia
Melbourne, Victoria, Australia
London, , United Kingdom
Toronto, Ontario, Canada
Birtinya, Queensland, Australia
Otahuhu, , New Zealand
Halifax, Nova Scotia, Canada
Oshawa, Ontario, Canada
London, , United Kingdom
Newcastle Upon Tyne, , United Kingdom
Sheffield, South Yorkshire, United Kingdom
Middlesbrough, , United Kingdom
Kingswood, New South Wales, Australia
Oakville, Ontario, Canada
Traralgon, Victoria, Australia
Manchester, , United Kingdom
Camperdown, New South Wales, Australia
Exeter, , United Kingdom
Westmead, New South Wales, Australia
Brisbane, Queensland, Australia
Bundaberg, Queensland, Australia
Hervey Bay, Queensland, Australia
Mackay, Queensland, Australia
Adelaide, South Australia, Australia
Armadale, Western Australia, Australia
Calgary, Alberta, Canada
Vancouver, Bristish Columbia, Canada
Scarborough, Ontario, Canada
Toronto, Ontario, Canada
Toronto, Ontario, Canada
Montreal, Quebec, Canada
Montréal, Quebec, Canada
Montréal, Quebec, Canada
Montréal, Quebec, Canada
Quebec City, Quebec, Canada
Takapuna, , New Zealand
Whangarei, , New Zealand
Cambridge, Cambridgeshire, United Kingdom
Nottingham, Nottinghamshire, United Kingdom
São Paulo, , Brazil
Edmonton, Alberta, Canada
Paris, , France
Porto Alegre, Rio Grande Do Sul, Brazil
Toronto, Ontario, Canada
Plymouth, Devon, United Kingdom
Airdrie, North Lanarkshire, United Kingdom
Middlesbrough, North Yorkshire, United Kingdom
Brighton, Sussex, United Kingdom
Dorchester, Dorset, United Kingdom
Sunderland, Durham, United Kingdom
Great Yarmouth, Norfolk, United Kingdom
Inverness, Scotland, United Kingdom
Shrewsbury, Shropshire, United Kingdom
Longueuil, Quebec, Canada
Stevenage, Hertfordshire, United Kingdom
York, North Yorkshire, United Kingdom
Bradford, West Yorkshire, United Kingdom
Birkenhead, Wirral, United Kingdom
Glasgow, Kent, United Kingdom
Stoke On Trent, Staffordshire, United Kingdom
Bury St Edmunds, Suffolk, United Kingdom
Campina Grande, Paraíba, Brazil
Cheltenham, , United Kingdom
Southend On Sea, , United Kingdom
Orillia, Ontario, Canada
Toronto, , Canada
Brisbane, Queensland, Australia
Townsville, Queensland, Australia
Melbourne, Victoria, Australia
Armadale, Washington, Australia
Barro Preto, , Brazil
Red Deer, , Canada
Toronto, , Canada
Toronto, , Canada
Jerusalem, , Israel
Jerusalem, , Israel
Bangkok, Khet Ratchathewi, Thailand
Campina Grande, , Brazil
Patients applied
Trial Officials
Sunil Badve
Principal Investigator
The University of Queensland
Ron Wald
Principal Investigator
St Michael's Hospital
Rona Smith
Principal Investigator
University of Cambridge
Suetonia Green
Principal Investigator
University of Otago
Patrick Mark
Principal Investigator
University of Glasgow
Rathika Krishnasamy
Principal Investigator
The University of Queensland
Michael Walsh
Principal Investigator
Hamilton Centre for Kidney Research
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials