Effect of Needle Size in Diagnostic Yield of EBUS-TBNA in Sarcoidosis and Lymphoma

Launched by CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (CHUM) · Jun 19, 2018

Keywords

ClinConnect Summary

This clinical trial is studying two different sizes of needles used during a procedure called EBUS-TBNA, which helps doctors collect samples from lymph nodes in the chest to diagnose conditions like sarcoidosis and lymphoma. The researchers want to find out if a larger, more flexible needle (the ViziShot FLEX 19G) can provide better samples for diagnosis compared to the standard smaller needle (22G). This is important because getting a good sample can help doctors determine the best treatment for patients.

To participate in the trial, you need to be between 65 and 74 years old, have lymph nodes that are suspicious for sarcoidosis or lymphoma, and be fit enough to undergo the procedure. You will be asked to give your consent, and if you qualify, you can expect to undergo the EBUS-TBNA procedure to collect samples. The study is currently recruiting participants, and your involvement could help improve the diagnostic process for these conditions in the future.

Gender

ALL

Eligibility criteria

• • Inclusion criteria
• • Patient t referred for specimens by EBUS -TBNA with clinical and radiological suspicion of sarcoidosis or lymphoma , with pathological lymph node on imaging (small diameter ≥ 1.0 cm CT-scan or hyper metabolism with PET scan) in para-tracheal stations, sub-carinal and / or hilar (stations 2, 4, 7, 10, 11 and 12), right and / or left.
• • Lymph nodes with a small diameter of at least 0.5 cm in CT-scan or PET / CT scan performed in the previous 4-6 weeks.
• • Patient investigated in the setting of either an initial diagnosis or a suspicion of lymphoma recurrence (post-treatment).
• • Patient able to consent to the procedure and to authorize us by written proxy, included in the consent form for the study, to obtain a copy of the subsequent results or radiological (PET, CT-scan, chest X-ray) or histopathological (linked with age sampled of intrathoracic lymph nodes).
• • Patient deemed fit to tolerate the procedure.
• • Exclusion criteria
• • Patient unable to give consent.
• • Female patient during pregnancy
• • Patient aged under 18.
• • Patient with significant coagulopathy ( INR \> 1.5 ; platelet count\<50 000 / mm 3 ).
• • Patient anticoagulated (oral or parenteral) and whose anticoagulation can not be suspended for the procedure.
• • Obvious involvement of organ (s) with the possibility of confirming granulomas or suspicious cells of lymphoma by means of a procedure considered less invasive (.. e g, lymph node biopsy of cervical, supraclavicular or inguinal nodes; skin biopsy).