Hemodynamics Monitoring During Lower Body Negative Pressure (LBNP) Induced Controlled Hypovolemia
Launched by YALE UNIVERSITY · Jul 9, 2018
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is focused on understanding how the body reacts to a condition called hypovolemia, which means having low blood volume. Researchers want to see how certain monitors and measurements change when healthy volunteers experience controlled hypovolemia using a method called lower body negative pressure (LBNP). This method simulates the effects of blood volume loss by creating a vacuum around the lower body, and the study aims to gather information that could help in managing patients with hemodynamic instability, which refers to unstable blood flow.
To participate in this trial, individuals must be healthy volunteers aged between 20 and 45 years old. Unfortunately, pregnant women, those under 20, and individuals with specific health conditions like heart disease, diabetes, epilepsy, or high blood pressure cannot join. Participants can expect to undergo monitoring while experiencing this controlled situation, contributing to important research that may improve our understanding of blood volume issues in patients.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • \* Healthy volunteers aged 20-45 with
- Exclusion Criteria:
- • Pregnant women
- • Under 20 years of age
- • Subjects with coronary artery disease, diabetes, epilepsy and hypertension
About Yale University
Yale University, a prestigious Ivy League institution located in New Haven, Connecticut, is renowned for its commitment to advancing medical research and clinical innovation. With a rich history of academic excellence and a robust infrastructure for scientific inquiry, Yale serves as a leading sponsor for clinical trials aimed at improving patient care and developing new therapeutic approaches. The university's multidisciplinary teams of researchers and clinicians collaborate to conduct rigorous and ethical studies, leveraging cutting-edge technologies and methodologies to address critical health challenges. Through its dedication to fostering an environment of inquiry and discovery, Yale University plays a pivotal role in translating research findings into clinical practice, ultimately enhancing health outcomes for diverse populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
New Haven, Connecticut, United States
Patients applied
Trial Officials
Aymen Alian, MD
Principal Investigator
Yale University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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