Epi Off Versus Epi on Corneal Collagen Cross-linking in Keratoconus Patients
Launched by UNIVERSITY OF MOLISE · Jul 14, 2018
Trial Information
Current as of May 06, 2025
Completed
Keywords
ClinConnect Summary
The aim of the study is to evaluate two different techniques of cross linking: standard epithelium off (CXL epi off) versus trans-epithelial (CXL epi on) cross linking in patient with progressive keratoconus.
Forty eyes from 32 patients with progressive keratoconus were prospectively enrolled from June 2014 to June 2015 in this non-blinded, randomized comparative study. Twenty eyes were treated by CXL epi off and 20 by CLX epi on, randomly assigned and followed for 2 years. All patients underwent a complete ophthalmologic testing that included uncorrected and best corrected visual acuity, ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • patients with evolving keratoconus
- • aged between 18 and 40 years
- • no evidence of corneal scarring
- Exclusion Criteria:
- • patients with central and paracentral corneal opacities
- • Vogt's striae
- • previous intraocular surgery
- • history of herpetic keratitis
- • history of severe dry eye
- • concomitant autoimmune diseases.
About University Of Molise
The University of Molise is a distinguished academic institution dedicated to advancing research and education in various fields, including medicine and health sciences. As a clinical trial sponsor, the university leverages its robust infrastructure and interdisciplinary expertise to facilitate innovative research initiatives aimed at improving patient outcomes and advancing medical knowledge. Committed to ethical standards and regulatory compliance, the University of Molise collaborates with healthcare professionals, researchers, and industry partners to conduct rigorous clinical trials that contribute to evidence-based practice and the development of new therapies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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