Hp129 Xenon Imaging and BOS in Lung Transplantation

Launched by CHILDREN'S HOSPITAL MEDICAL CENTER, CINCINNATI · Jul 20, 2018

Keywords

ClinConnect Summary

This clinical trial, called the Hp129 Xenon Imaging and BOS in Lung Transplantation study, is looking at new ways to take pictures of the lungs to help doctors find problems earlier in patients who have had a lung transplant. One common issue that can develop after a lung transplant is called Bronchiolitis Obliterans Syndrome (BOS), which affects many patients and can lead to serious complications. By using special imaging techniques, researchers hope to spot changes in the lungs sooner, which could lead to better treatments and outcomes for patients.

To participate in this trial, you need to have had a lung transplant within the last 10 years or be evaluated for a possible transplant. You should also be able to hold your breath for up to 16 seconds during the imaging process. Participants will undergo imaging tests and may have small lung tissue samples (biopsies) taken to help with future research. It’s important to know that some individuals may not be eligible if they have certain health conditions, are pregnant, or have respiratory infections. Overall, this study aims to enhance the care and monitoring of lung transplant patients, potentially improving their long-term health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Lung Transplantation within the last 10 years or being assessed for possible lung transplantation.
• • Participant must be able to hold their breath for up to 16 seconds.
• Exclusion Criteria:
• • Standard MRI exclusion criteria
• • Bleeding disorders
• • Participant is claustrophobic or otherwise unable to tolerate the imaging
• • Pregnancy or positive pregnancy test
• • Symptoms of respiratory infection within the past two weeks.
• • Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula.