Adjunctive Treatment for Chronic Rhinosinusitis With Nasal Polyposis

Launched by MARINA BORUK · Jul 23, 2018

Keywords

ClinConnect Summary

This clinical trial is investigating a new treatment option for patients with chronic rhinosinusitis and nasal polyps. Researchers want to see if a foam called carboxymethylcellulose (often shortened to CMC), combined with a steroid medication, is more comfortable after surgery and just as effective as a currently approved device that releases steroids. The study will involve about 30 participants who will receive both treatments—one in each nostril—so that researchers can compare the results. Participants will complete surveys about their symptoms and have pictures taken of their nasal cavities at various points after surgery to track their progress.

To qualify for this study, participants should be between the ages of 18 and 74, have a diagnosis of nasal polyps, and be planning to have surgery. They must also be able to commit to all study procedures and cannot have certain health issues, like a known allergy to steroids or specific eye conditions. Throughout the study, participants will provide feedback on their recovery and quality of life, helping researchers determine which treatment option is best in the early days after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Provision of signed and dated informed consent form
• • Stated willingness to comply with all study procedures and availability for the duration of the study
• • Diagnosis of nasal polyposis and desiring surgery
• Exclusion Criteria:
• • A known history of intolerance to corticosteroids
• • An oral steroid-dependent condition
• • A history of immune deficiency
• • Pre-existing narrow angle glaucoma or cataracts
• • Subjects that did not complete the pre-op medical regimen described below
• • Pregnant and/or breastfeeding