Hydrocortisone Vs Prednisolone in AI (HYPER-AID)

Launched by IMPERIAL COLLEGE LONDON · Jul 31, 2018

Keywords

ClinConnect Summary

The HYPER-AID trial is a study looking at how two different medications, hydrocortisone and prednisolone, affect people with adrenal insufficiency, a condition where the body doesn’t produce enough hormones. The trial aims to collect information on how switching between these two treatments impacts individuals’ physical health, hormone levels, and overall well-being.

To participate in this study, you need to be between 18 and 85 years old and have been diagnosed with adrenal insufficiency for at least six months. You should also have been on a stable dose of either hydrocortisone or prednisolone for the last four months. If you meet these criteria and are willing to provide written consent, you may be eligible to join. Participants can expect to share their health experiences and undergo some assessments to help researchers understand the differences between the two treatments. It's important to note that women who are pregnant or using certain contraceptives may not be able to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18 - 85 years
• • Male or female
• • Diagnosed with adrenal insufficiency (AI) for over 6 months according to standard diagnostic criteria
• • Established on stable hydrocortisone or prednisolone replacement, dose not altered for at least 4 months
• • Individuals taking other hormone replacements are accepted providing that their replacement doses have not altered for at least 3 months;
• • Individuals who are able and willing to give written informed consent to participate in the study
• Exclusion Criteria:
• • Individuals who are unable to give informed consent
• • Pregnancy (determined by patients self-reporting pregnancy status)
• • Patients using the combined oral contraceptive pill