Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients

Launched by GARY L. PIERCE · Jul 26, 2018

Keywords

ClinConnect Summary

COPD is a global health concern affecting more than 65 million people worldwide. In the U.S. alone, the estimated medical costs attributed to COPD surpassed $30 billion in 2010. A high percentage of this healthcare cost is attributed to the management of comorbidities associated with COPD, such as CVD. Although primarily a disease of the lungs, CVD accounts for up to 50% of all deaths among individuals with COPD. One likely mechanism contributing to the increased CVD risk observed in individuals with COPD is large central artery (i.e. carotid and aorta) stiffness. Elevated large artery stif...

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Eligibility criteria

• Inclusion Criteria:
• • Age 30-80
• • Ability to comfortably lie flat for 2 hours
• • Normal/corrected hearing and vision
• • English speaking
• • Airway predominate phenotype of COPD
• Exclusion Criteria:
• • Other concomitant respiratory disorder (including asthma)
• • Use of antibiotics or steroids for a COPD exacerbation within the past month
• • Use of 24-hour oxygen
• • Pregnancy or suspected pregnancy
• • Uncontrolled cancer within the last 5 years
• • Radiation therapy to the chest
• • Lung surgery (LVRS, transplant, lobectomy)
• • Lung cancer known or suspected
• • Insulin-dependent diabetes
• • Inability to use an inhaler bronchodilator
• • Eye surgery in the last 5 weeks
• • Chest or abdominal surgery in the past 3 months
• • Heart attack in the last 3 months
• • Hospitalization for any heart problem in the past month
• • Renal failure
• • Heart failure
• • Substance use disorder
• • Cystic fibrosis
• • Glaucoma
• • Prostate disorder
• • Allergy to milk or milk products
• • Cardiac arrhythmia
• • Currently using a LAMA/LABA combination bronchodilator