Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease

Launched by NATIONWIDE CHILDREN'S HOSPITAL · Aug 8, 2018

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging technique called radiotracer-based perfusion imaging to better understand blood flow in patients with Peripheral Artery Disease (PAD), diabetes, and chronic limb-threatening ischemia. The goal is to create a healthy database for this imaging method and to find out how well it can predict outcomes for patients who are having surgery to improve blood flow in their legs. Researchers believe that this non-invasive imaging will help identify issues in blood flow to the muscles and evaluate how well treatments are working.

To participate in this trial, you need to be at least 18 years old and have significant blockages in one or more arteries in your legs, confirmed by previous tests. Healthy volunteers who do not have PAD can also join the study, but they must also be over 18 and have no history of PAD. Throughout the trial, participants will undergo imaging tests, and those with PAD will have their blood flow evaluated to see how it responds to treatment. This study is currently recruiting participants of all genders, and it aims to improve understanding and treatment of PAD for better patient outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for Patients with Peripheral Artery Disease:
• • 1. At least 18 years of age
• • 2. Evidence of significant obstructive disease for one or multiple lower extremity arteries, as identified by prior ABI, TBI, CT angiography, ultrasound, or MR imaging.
• Exclusion Criteria for Patients with Peripheral Artery Disease:
• • 1. Unable to give informed consent or follow-up
• • 2. Pregnant or nursing
• • 3. Under the age of 18
• • 4. No history of peripheral artery disease
• Inclusion Criteria for Healthy Control Subjects:
• • 1. At least 18 years of age
• • 2. No evidence or prior diagnosis of peripheral artery disease based on chart review and standard vascular screening.
• Exclusion Criteria for Healthy Control Subjects:
• • 1. Unable to give informed consent of follow-up
• • 2. Pregnant or nursing
• • 3. Under the age of 18
• • 4. History of peripheral artery disease