Spironolactone Versus Indapamide in Obese and Hypertensive Patients

Launched by PEKING UNIVERSITY THIRD HOSPITAL · Aug 3, 2018

Keywords

ClinConnect Summary

Thiazide diuretics have been widely used for the management of essential hypertension, especially in patients with salt-sensitive hypertension. Most recent guidelines continue to recommend thiazide diuretics as first-line agents for all patients with hypertension in spite of the potential metabolic side effects such as hypokalemia, hypertriglyceridemia, impaired glucose tolerance and increases in serum cholesterol and uric acid. However, mineralocorticoid receptor antagonists (MRAs), such as spironolactone or eplerenone, are mainly recommended to be used in patients with resistant hypertens...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with essential hypertension aged between 18-80years
• • 2. Office systolic blood pressure (SBP)≥140mmHg and \<180mmHg without treatment or on one antihypertensive drug or SBP\<140mmHg on two antihypertensive drugs
• • 3. Waist circumference ≥90cm for males, ≥ 80cm for females
• Exclusion Criteria:
• • 1. Secondary hypertension.
• • 2. Symptomatic congestive heart failure or history of heart failure.
• • 3. History of ischemic stroke, unstable angina or myocardial infarction;
• • 4. Atrial fibrillation
• • 5. Serum creatinine ≥ 2.0mg/dl or eGFR≤ 30 ml/min/1.73 m2
• • 6. Serum K+ ≥ 5.0 mmol/L or ≤3.5 mmol/L