High Flow Oxygen and Non Invasive Ventilation for Hypercapnic Respiratory Failure
Launched by UNIVERSITY HOSPITAL, MAHDIA · Aug 8, 2018
Trial Information
Current as of June 20, 2025
Unknown status
Keywords
ClinConnect Summary
High Flow Nasal Cannula (HFNC) is a new way of oxygen therapy that has gained interest in the management of patients with acute respiratory failure. It allows reaching a high flow air up to 60 liters / min via a nasal cannula with a humidification and warming of the air administered. It has a number of physiological effects such as wash out of anatomical dead space, generation of a small PEEP and high inspired fraction of oxygen which enhances compliance and reduces inspiratory efforts.
NIV is the corner stone in the treatment of severe COPD exacerbation. Nevertheless, prolonged applicatio...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients aged more than 18 years with a diagnosis of acute-on-chronic respiratory failure and respiratory acidosis requiring NIV.
- Exclusion Criteria:
- • Patient included in another study
- • Patients intubated at ICU admission or within 12 hours
- • Contraindication to NIV including: pneumothorax, Hemodynamic instability, GCS less than 12, facial malformation
- • Asthma
- • A do not intubate order
- • Neuromuscular disease
About University Hospital, Mahdia
University Hospital Mahdia is a leading academic medical institution dedicated to advancing healthcare through innovative research and clinical trials. Located in Mahdia, Tunisia, the hospital combines cutting-edge medical practices with a commitment to patient-centered care. As a sponsor of clinical trials, University Hospital Mahdia plays a pivotal role in the evaluation of new therapies and treatment protocols, fostering collaboration between researchers, healthcare professionals, and the community. With a focus on enhancing medical knowledge and improving patient outcomes, the hospital is at the forefront of clinical research in the region.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Mahdia, , Tunisia
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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