Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery

Launched by PEKING UNIVERSITY FIRST HOSPITAL · Aug 13, 2018

Keywords

ClinConnect Summary

This clinical trial is studying how managing blood pressure during surgery can help prevent kidney problems after heart surgery, specifically a procedure called off-pump coronary artery bypass grafting (CABG). Researchers believe that keeping blood pressure at a targeted level during the surgery may lower the risk of acute kidney injury (AKI), which is a common complication that can lead to worse health outcomes after surgery.

To participate in this trial, you need to be at least 50 years old and scheduled for off-pump CABG surgery. Unfortunately, if you have severe high blood pressure that is not treated, serious kidney disease, or certain other health issues, you may not be eligible. If you join the study, you will receive careful monitoring of your blood pressure during your surgery to see if this approach can help protect your kidneys. This trial is currently recruiting participants, and your involvement could contribute to important findings that may improve care for future patients undergoing similar surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 50 years;
• • Scheduled to undergo off-pump CABG surgery.
• Exclusion Criteria:
• • Refuse to participate;
• • Untreated or uncontrolled severe hypertension (systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg);
• • Chronic kidney disease with a glomerular filtration rate \< 30 ml/min/1.73 m2 or end-stage renal disease requiring renal-replacement therapy;
• • Inability to communicate during the preoperative period because of coma, profound dementia, language barrier, or end-stage disease;
• • Requirement of vasopressors/inotropics to maintain blood pressure before surgery;
• • Second or emergency surgery;
• • Expected survival of less than 24 hours.