Timing of Renal Replacement Therapy in the Critically Ill Patients

Launched by KAROLINSKA UNIVERSITY HOSPITAL · Aug 13, 2018

Keywords

ClinConnect Summary

This clinical trial is studying the best timing for starting renal replacement therapy (RRT), a treatment for severe kidney injury, in critically ill patients. Researchers want to find out whether beginning this treatment early can lead to better outcomes, such as fewer deaths and improved recovery. The study will analyze data from over 60,000 patients admitted to intensive care units in Stockholm, and it will look at different ways to define "early" and "late" treatment based on various health indicators.

To participate in the trial, patients must be over 18 years old and admitted to the intensive care units at specific hospitals in Stockholm. Unfortunately, individuals who are under 18, have a "do not resuscitate" order, or pass away within 12 hours of starting RRT cannot join. Participants can expect their health outcomes to be monitored for up to three years, helping researchers understand the impact of when RRT is started on survival and recovery. This trial is currently recruiting participants, and it aims to fill a vital gap in knowledge about treating critically ill patients with kidney problems.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • \*Critically ill patients admitted to intensive care units in Stockholm at: Karolinska University Hospital (Solna and Huddinge) and at Södersjukhuset.
• • \*Patients over 18 years of age
• Exclusion Criteria:
• • Patients \<18 years
• • Patients with DNAR (do not attempt resuscitation)-orders
• • Patients dying within 12 hours of commencing renal replacement therapy.