Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain
Launched by WOMEN'S COLLEGE HOSPITAL · Aug 21, 2018
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying different ways to help manage pain after surgery for an Anterior Cruciate Ligament (ACL) injury. Specifically, researchers want to find out if adding certain medications—dexamethasone, dexmedetomidine, or a combination of both—to a pain relief technique called the Adductor Canal Block (ACB) can reduce discomfort after the operation. The study is currently looking for participants aged 18 to 62 who speak English and meet certain health criteria, such as having a Body Mass Index (BMI) under 40 and being in good physical condition.
If you decide to participate, you will receive either one of the medications, a combination of both, or a placebo (a treatment that has no active ingredients) along with the ACB to help manage your pain after surgery. It's important to note that there are some criteria that could exclude you from joining, such as certain medical conditions, a history of substance dependence, or if you cannot give informed consent. Overall, this trial aims to improve pain management strategies for people recovering from ACL repair surgery, which could lead to better recovery outcomes.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • English Speaking
- • ASA 1-3 patients
- • BMI \<40
- Exclusion Criteria:
- • Refusal or inability to provide informed consent
- • Any contraindication to regional anesthesia including coagulopathy or bleeding diathesis, allergy to local anesthetics, infection, nerve injury or malignancy at the site of the block
- • History of alcohol/drug dependence
- • History of long term opioid intake or chronic pain disorder
- • History of preexisting neuropathy in the operative leg
- • History of significant psychiatric conditions that may affect patient assessment
- • Inability to understand the informed consent and demands of the study
- • Allergy to any of the components of the multimodal analgesic regimen
- • Revision of ACL repair
- • Diabetes
- • Significant bradycardia (baseline heart rate ≤ 40 beats per minute)
About Women's College Hospital
Women's College Hospital (WCH) is a leading academic health sciences center in Toronto, dedicated to advancing women's health through innovative research, education, and exceptional patient care. As a progressive institution, WCH focuses on addressing the unique health needs of women, fostering groundbreaking clinical trials that contribute to the understanding and treatment of various health conditions. With a commitment to collaboration, WCH partners with various stakeholders, including academic institutions and healthcare organizations, to enhance the quality of care and improve health outcomes for women. Through its robust research programs, Women's College Hospital is at the forefront of shaping future healthcare practices and policies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Toronto, Ontario, Canada
Patients applied
Trial Officials
Richard Brull, MD
Principal Investigator
Women's College Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials