Intracameral Versus Intravitreal Bevacizumab Injection in NVG: RCT

Launched by PRINCE OF SONGKLA UNIVERSITY · Aug 24, 2018

Keywords

ClinConnect Summary

This clinical trial is studying two different ways of giving a medicine called Bevacizumab to people with neovascular glaucoma, a type of eye condition where new, abnormal blood vessels grow and cause high pressure inside the eye. The trial compares injections of the medicine into two different parts of the eye to see which method works better and is safer.

To join the study, participants must be adults diagnosed with neovascular glaucoma who have high eye pressure and are scheduled for a certain eye surgery called trabeculectomy. They also need to have some vision left, at least enough to see hand movements. People with certain other eye problems, allergies to the medicine, active eye infections, or serious health issues like heart disease or uncontrolled blood pressure cannot join. Participants will receive one of the two types of injections and will need to come back for follow-up visits to check how well the treatment is working and to monitor safety. If you or a family member fit these criteria and want to learn more, this study might be an option to consider.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Diagnosis of neovascular glaucoma
• • 2. The patients having IOP \> 21 mmHg, having the indication for trabeculectomy
• • 3. The patients' age of at least 18-year-old
• • 4. The patients having visual potential at least hand motion.
• • 5. Present of NVI or NVA.
• • 6. Willing and able to provide informed consent to participate in the study
• • 7. Able to understand the purpose of the study, his/her role, and is available to return to the clinic/hospital for all required follow-up visits
• Exclusion Criteria:
• • 1. One eye patient
• • 2. Patients having severe corneal edema or total hyphema obscure NVI or NVA view.
• • 3. Cannot obtain endothelial cell count.
• • 4. History of bevacizumab or fluorescence dye allergy.
• • 5. Active infectious ocular disease including endophthalmitis and corneal ulcer
• • 6. History of systemic disease including ischemic heart disease, cerebrovascular disease, end-stage renal disease, liver failure, uncontrolled hypertension
• • 7. Has or planning to be pregnant or breastfeeding