Investigation of Neurophysiological Markers, Possibly Specific of Two Subforms of Psychotic Disorders

Launched by UNIVERSITY HOSPITAL, STRASBOURG, FRANCE · Aug 27, 2018

Keywords

ClinConnect Summary

This clinical trial is looking at different types of psychotic disorders, specifically schizophrenia, to understand them better and find more personalized treatments. Researchers believe that by identifying specific subforms of these disorders, they can learn more about their causes and how they affect people in different ways. The study will compare two distinct subforms known since the 1970s, using various assessments, brain imaging (fMRI), and tests that measure emotions and movement. They hope to find clear differences between these subforms, which could lead to better ways to manage and treat them.

To participate, individuals must be between the ages of 65 and 74 or 23 and 740, and either have schizophrenia or schizo-affective disorder. They should also be stable in their condition for at least two months and willing to sign consent forms. Both patients and healthy controls can join, but certain health issues, like severe illnesses or neurological disorders, may disqualify someone. Participants can expect to undergo a range of assessments, including brain scans, to help researchers gather important insights on these disorders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • for both patients and controls
• • male or female willing to participate and who have signed up the legal document
• • under the protection of health insurance for patients only
• • schizophrenia or schizo-affective disorder according to the DSM-5 criteria
• • periodic catatonia or hebephrenia accordin to WKL classification
• • clinically stable for at least 2 months
• • in or out patients for controls only
• • no psychiatric history
• Exclusion Criteria:
• • for both patients and controls
• • current severe or unstable somatic illness
• • neurological history (epilepsia, brain injury, brain surgery...)
• • current substance use disorder (DSM-5)
• • current major depressive disorder (DSM-5)
• • mental retardation (IQ \< 70)
• • pregnancy, breast feeding
• • current legal control
• • contra-indication for fMRI for controls only psychotropic intake during the last 3 weeks