A Prospective Cohort Study of Patients Suffering From Hand Osteoarthritis Symptoms

Launched by UNIVERSITY HOSPITAL, MONTPELLIER · Aug 24, 2018

Keywords

ClinConnect Summary

This clinical trial is looking at patients with early symptoms of hand osteoarthritis (OA), which is a condition that can cause pain and stiffness in the joints. The goal is to find ways to identify these early symptoms using special imaging techniques like ultrasound and MRI. By understanding who is at a higher risk for worsening OA, doctors hope to improve treatment options and outcomes for patients.

To join the study, participants need to be between the ages of 65 and 74 and have early signs of hand OA, such as pain, swelling, or stiffness in their finger joints. They should also be under 60 years of age when they first noticed these symptoms, and these symptoms should have been changing for less than three years. Participants will need to sign a consent form and may undergo imaging tests. It's important to note that individuals with certain other medical conditions, like rheumatoid arthritis or advanced OA, cannot participate. This study is currently recruiting participants, and it aims to help improve how we understand and treat hand osteoarthritis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Early digital osteoarthritis must combine the clinical AND radiological definition.
• Clinical definition:
• • At least one of the following 4 criteria: Pain or stiffness or swelling or deformity of a digital joint (IPP and / or IPD) A breach of at least one PPI and / or IPD Age under 60 at the time of the first symptoms Clinical symptoms have been changing for less than 3 years
• Radiographic definition:
• • The presence of the achievement of at least one PPI and / or IPD. Presence of at least two of the following three criteria: pinching, marginal subchondral condensation, marginal osteophyte Erosion on radiography is not an exclusion criteria
• • - Consent form signed
• Exclusion criteria:
• • patients suffering from rheumatoid arthritis, rheumatoid psoriasis or any other inflammatory rheumatism
• • patients suffering from metabolic diseasis such as gout, hemochromatosis, Wilson's disease; or from congenital disease such as displasie, osteogenesis,
• • Presence of advanced radiographic osteoarthritis based in Kellgreen Lawrence score (=4) in one joint among the 10 previous sites.
• • Not able to provide a sample of blood for any reasons
• • MRI contraindication
• • Being in exclusion period determined by another previous study
• • Subject non affiliated to social insurance
• • Pregnant or lactating women
• • Vulnerable people based in L1121-5 article of CSP
• • Elderly subject or protected subjects disabled to give their consent
• • Subjects private of freedom by court or administrative order