T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias
Launched by PAUL SZABOLCS · Aug 28, 2018
Trial Information
Current as of July 22, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a new type of bone marrow transplant for patients with severe sickle cell disease and other similar conditions, like beta-thalassemia and Diamond-Blackfan anemia. The goal is to see how effective a transplant from matched but not perfectly compatible donors can be, using a method that reduces the risk of complications known as graft-versus-host disease. This approach could help more patients receive the transplants they need.
To be eligible for the trial, participants should be between 5 and 40 years old and have specific complications from their condition, like frequent painful episodes or a need for regular blood transfusions. Additionally, they must have tried other treatments without success. During the study, participants will receive careful monitoring and support, as well as detailed medical evaluations to ensure their safety. It's important to note that this trial is currently recruiting, and all patients will need to provide consent before joining.
Gender
ALL
Eligibility criteria
- • Inclusion Criteria
- • 1. Patient, parent, or legal guardian must have given written informed consent and/or assent according to FDA guidelines.
- • 2. Ages 5 years to 40 years, at time of consent.
- 3. Diagnosis of Sickle Cell Disease (Hemoglobin SS, Sβ0-thalassemia) complicated by any of the following:
- • Recurrent acute painful episodes (also known as vaso-occlusive crises; VOC) despite supportive care, minimum of 2 new pain events per year requiring hospitalization for parenteral pain management in the previous 2 years.
- • Recurrent acute chest syndrome (ACS) despite supportive care, minimum of 2 episodes in preceding 2-year period.
- • Stroke or neurologic event lasting \> 24 hours with an accompanying infarct on MRI in any patient for all ages; Brain MRI with silent infarct without clinical event in patients ≤ 16 years.
- • Chronic transfusion therapy defined as \> 8 packed red blood cell transfusions per year in the year prior to enrollment and/or evidence of red blood cell alloimmunization.
- • Elevated transcranial Doppler velocities - \> 200 cm/s, via the non-imaging technique or \> 185 cm/s by the imaging technique measured on 2 separate occasions ≥ 1-month apart
- • Elevated TRV \> 2.6m/s in patients ≥ 16 years old.
- • Sickle-related renal insufficiency and/or sickle hepatopathy and/or any irreversible end-organ damage in patients ≥ 16 years old.
- • OR Diagnosis of beta-thalassemia or Diamond-Blackfan anemia complicated by transfusion dependence with evidence of iron overload.
- • 4. A minimum donor match of 4/8 via high resolution HLA typing at HLA-A, -B, -C, -DRB1 loci in the related setting or minimum donor match of 6/8 via high resolution HLA typing at HLA-A, -B, -C, -DRB1 loci (with the DRB1 locus as a full match requirement). An unrelated donor and cord blood search must have been completed without an eligible 8/8 matched unrelated donor or 6/8 cord blood unit available. Patients who may have acceptable cord blood donor options (4/6 or better) but are limited by cell dose of a single cord will also be eligible for the proposed study.
- 5. Adequate function of other organ systems as measured by:
- • Creatinine clearance or GFR ≥ 45 ml/min/1.73m.
- • Hepatic transaminases (ALT/AST) ≤ 3 x upper limit of normal.
- • Liver MR imaging for iron content should be performed in all patients with Ferritin \> 500 ng/mL. If hepatic iron content \> 10mg Fe/g liver should have hepatology consultation and liver biopsy to confirm absence of cirrhosis, fibrosis or hepatitis.
- • Adequate cardiac function as measure by echocardiogram (shortening fraction \> 26% or ejection fraction \> 40% or \>80% of age-specific normal).
- • Pulmonary evaluation testing demonstrating FEV1/FVC ≥ 60% of predicted for age and/or resting pulse oximeter ≥ 92% on room air.
- • Cardiology clearance to proceed with conditioning regimen and HSCT.
- • Pulmonology clearance to proceed with conditioning regimen and HSCT.
- • 6. Subjects must be human immunodeficiency virus (HIV) negative by PCR.
- • 7. Negative pregnancy test for females ≥10 years old or who have reached menarche, unless surgically sterilized.
- • 8. All females of childbearing potential and sexually active males must agree to use an FDA approved method of birth control for up to 24 months after BMT or for as long as they are taking any medication that may harm a pregnancy, an unborn child or may cause a birth defect.
- • 9. Subject and/or parent guardian will also be counseled regarding the potential risks of infertility following BMT and advised to discuss sperm banking or oocyte harvesting (Refer to section,
- • 10. Hydroxyurea must have been trialed and failed in patients with sickle cell disease.
- • Patient Exclusion Criteria
- • 1. Patients with alternate, superior donor options (matched sibling donor or matched unrelated donor).
- • 2. Patients who have undergone stem cell transplantation in the 6 months prior to anticipated conditioning.
- • 3. Patients with history of a central nervous system (CNS) event within six months prior to start of conditioning (patient will be delayed until eligible).
- • 4. Patients who are pregnant or lactating
- • 5. Patients with uncontrolled bacterial, viral or fungal infection
- • 6. Past or current medical problems or findings from physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.
About Paul Szabolcs
Dr. Paul Szabolcs is a distinguished clinical trial sponsor and researcher specializing in pediatric hematology and oncology. With extensive experience in conducting innovative clinical trials, he is dedicated to advancing treatment options for children with hematologic malignancies and other complex disorders. Dr. Szabolcs is committed to integrating cutting-edge research with compassionate care, ensuring that his trials not only meet rigorous scientific standards but also prioritize the well-being of participants. His collaborative approach fosters partnerships with leading institutions and stakeholders, driving forward the development of effective therapies that can significantly improve patient outcomes.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Pittsburgh, Pennsylvania, United States
Patients applied
Trial Officials
Paul Szabolcs, MD
Principal Investigator
University of Pittsburgh
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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