Modulating Inhibitory Control Networks in Gambling Disorder With Theta Burst Stimulation

Launched by CNS ONLUS · Sep 11, 2018

Keywords

ClinConnect Summary

This clinical trial is studying a treatment for people with Gambling Disorder, a condition that can lead to serious problems in a person's life. The researchers want to see if a technique called theta burst stimulation (TBS), which uses magnetic fields to stimulate specific areas of the brain, can help improve control over gambling urges and reduce symptoms. In this study, 40 participants will be randomly assigned to receive either the active treatment or a fake treatment (placebo) for two weeks. The researchers will also use brain imaging and behavioral tests to understand how the treatment works and if it helps improve the participants' condition.

To take part in the study, participants must be between 18 and 65 years old and have a diagnosis of Gambling Disorder. However, people with other serious mental health issues, recent hospitalizations, or certain medical conditions will not be eligible. Those who join can expect to have their brain activity monitored and to participate in sessions that involve TBS. Overall, the trial aims to find new ways to help individuals struggling with gambling problems and to learn more about how the brain processes these behaviors.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. DSM-5 diagnosis of Gambling Disorder
• • 2. Age between 18 and 65 years
• Exclusion Criteria:
• • 1. any additional current psychiatric comorbidity, except for nicotine addiction;
• • 2. a lifetime DSM-5 diagnosis of schizophrenia or other psychotic syndromes, substance dependence or substance abuse, including alcohol, bipolar I or II disorder, mental disorder due to a general medical condition;
• • 3. serious suicide risk;
• • 4. illness duration less than two years;
• • 5. hospitalization in the last 6 months;
• • 6. the inability to receive TMS because of metallic implants, or history of seizures (personal or family history of seizure in first degree relatives);
• • 7. any major medical disease;
• • 8. pregnancy or nursing of an infant;
• • 9. the inability or refusal to provide written informed consent.