Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Launched by STANFORD UNIVERSITY · Sep 20, 2018

Keywords

ClinConnect Summary

This clinical trial is investigating a new approach to prevent a condition known as ventilator-induced diaphragm dysfunction (VIDD), which can happen when patients are on a ventilator for a long time. The trial aims to test a drug that blocks certain processes in the body that can lead to diaphragm injury, which is important for breathing. If successful, this study could pave the way for larger trials to help protect patients' diaphragm function while they are receiving critical care.

To be eligible for this trial, participants should be between the ages of 65 and 74 and scheduled to undergo a specific surgery called esophagectomy. However, people with certain health issues, like serious lung problems, neuromuscular diseases, or those who are pregnant, cannot participate. If you join the study, you will be monitored to see if the drug helps prevent diaphragm injury while you are being treated in the hospital. The researchers hope this investigation will lead to better care for patients on ventilators in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing esophagectomy
• Exclusion Criteria:
• • Patients with more than mild pulmonary dysfunction
• • Patients with any neuromuscular disease that might compromise diaphragm function
• • Patients with abnormal liver or kidney function
• • Patients taking any immunosuppressant medication (including prednisone) or antifungal medications
• • History of tuberculosis
• • Weight loss of \>5% of body weight over previous 6 months
• • Pregnancy