Peri-Procedural Transmural Electrophysiological (EP) Imaging of Scar-Related Ventricular Tachycardia

Launched by JOHN SAPP · Oct 18, 2018

Keywords

ClinConnect Summary

This clinical trial is studying a new approach to improve the treatment of ventricular tachycardia (VT), a serious heart condition that can lead to sudden cardiac death. The trial aims to enhance the effectiveness of a treatment called catheter ablation, which is used to block the abnormal electrical pathways in the heart that cause VT. By using advanced imaging techniques, the researchers hope to better identify the areas that need treatment before the procedure and understand why some treatments may not work afterward.

To participate in this trial, you may be eligible if you have experienced at least one episode of sustained VT and have been referred for catheter ablation. You should also have a previously implanted implantable cardioverter-defibrillator (ICD) and be willing to follow all the study requirements. Participants can expect to undergo imaging scans and potentially receive the catheter ablation treatment as part of the study. This trial is open to adults aged 65 to 74 and aims to gather important information that could lead to better outcomes for patients with VT.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • One or more episodes of sustained monomorphic VT
• • Referred for catheter ablation
• • Previously implanted ICD
• • Signed the patient informed consent form
• • Able and willing to comply with all pre-, post-, and follow-up testing and requirements
• Exclusion Criteria:
• • Have estimated Glomerular Filtration Ratio (eGFR) less than 30
• • Have a life expectancy less than 6 months or are listed for heart transplantation at time of inclusion
• • Are pregnant
• • Are on IV inotropic agents
• • Have any contraindication to catheter ablation (including but not limited to mechanical prosthetic aortic and mitral valves, known protruding Left Ventricular (LV) thrombus
• • New York Heart Association (NYHA) functional class IV
• • Had ST wave elevation myocardial infarction within \< 1 month
• • Unwilling or unable to undergo cardiac MRI scan AND unwilling or unable to undergo cardiac CT scan (e.g. contrast allergy).