Spectroscopy in Functional Assessment of Peripheral Artery Disease (spectroAMI)

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE · Oct 26, 2018

Keywords

ClinConnect Summary

The clinical trial titled "Spectroscopy in Functional Assessment of Peripheral Artery Disease" (spectroAMI) is studying how well a special imaging technique called P-31 MR spectroscopy can help assess the function of mitochondria in patients with peripheral arterial occlusive disease (PAOD). This condition causes reduced blood flow to the legs, often leading to pain during physical activity (called claudication). By understanding mitochondrial function, researchers hope to find better ways to evaluate and treat this disease.

To participate in this trial, you should be between the ages of 65 and 75 and have been diagnosed with PAOD, specifically with a blockage in the main arteries of the leg. You must also have a specific measurement of blood flow in your legs (ABI) and be planning for surgery. However, some people may not qualify, such as those with certain medical devices like pacemakers, recent severe leg pain, or uncontrolled high blood pressure. If you join the study, you can expect to undergo non-invasive imaging tests and will be closely monitored by medical professionals. This research could help improve future treatments for people with similar conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Peripheral arterial occlusive disease (PAOD) with claudication and surgery planning with proximal lesion (iliac or femoral (x-ray angiography or CT or MRA) and no distal lesions (doppler)
• • ABI\<0.90 or \>1.30
• • signed consent form
• • health insurance coverage
• Exclusion Criteria:
• • Contraindication in the practice of MRI: pacemaker, metallic cardiac valve, intra-ocular metal part, claustrophobia
• • critical ischemia \>15 days
• • Type 1 or 2 diabetes
• • weight \>200kg
• • non stabilized hypertension
• • beta-blockers
• • non-atherosclerotic vascular occlusive disease (Buerger disease, Takayasu disease, venous disease, trapped popliteal artery etc..)
• • Neurological pathology/non-voluntary contraction