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Search / Trial NCT03725579

Anesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine

Launched by CAIRO UNIVERSITY · Oct 29, 2018

Trial Information

Current as of August 15, 2025

Unknown status

Keywords

Anesthetic Efficacy Inferior Alveolar Nerve Blocks

ClinConnect Summary

Sixty-six patients diagnosed clinically and radiographically with symptomatic irreversible pulpitis in mandibular posterior teeth will received single-visit root canal treatment using ProTaper Universal rotary system for canal preparation, then they will be randomly divided into two groups (n=33) according to the anesthetic solution used, either Group M (3.6 ml Mepivacaine hydrochloride 2% with 1:100000 epinephrine) or Group A (3.4 ml Articaine hydrochloride 4% with 1:100000 epinephrine). The pain will be assessed using numerical rating scale (NRS) during access cavity preparation and instr...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1. Patients in good health (American Society of Anesthesiologists Class II or higher)
  • 2. Patients having symptomatic irreversible pulpitis in one of their mandibular molars.
  • 3. Age range is between 20 and 50 years.
  • 4. Patients who can understand Visual Analogue Scales VAS.
  • 5. Patients able to sign informed consent
  • Exclusion Criteria:
  • 1. Patients allergic to articaine and/or mepivacaine and/or sulfur
  • 2. Patients having active sites of pathosis in the area of injection.
  • 3. Patients having active pain in more than one molar.
  • 4. Patients who had taken analgesics in the 12 hours preceding the injection.

About Cairo University

Cairo University, a premier institution in Egypt, is dedicated to advancing medical research and education through innovative clinical trials. With a strong emphasis on improving healthcare outcomes, the university collaborates with various stakeholders to conduct rigorous scientific studies that address critical health challenges. Leveraging its extensive resources and expert faculty, Cairo University aims to contribute valuable insights to the medical community and enhance patient care both locally and globally. Through its commitment to ethical research practices and excellence, the university plays a pivotal role in shaping the future of healthcare in the region.

Locations

Cairo, , Egypt

Patients applied

0 patients applied

Trial Officials

Marwa Bedier, PHD

Study Director

Cairo university, faculty of dentistry

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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