Nitrous Oxide- Suicidal Ideation

Launched by WASHINGTON UNIVERSITY SCHOOL OF MEDICINE · Nov 7, 2018

Keywords

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients aged 18-65 years old;
• • 2. current diagnosis of unipolar, major depressive disorder (MDD) without psychosis as defined by the Mini-International Neuropsychiatric Interview (MINI) and The Fourth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) DSM-IV determined by clinical interview and by a baseline score of ≥18 on the HDRS-21 (Hamilton Depression Rating Scale 21-item;
• • 3. moderate to severe SI defined as a score ≥3 on the HDRS-21 suicide item (item #3);
• • 4. will have good command of the English language;
• • 5. will have been voluntarily admitted to the inpatient Psychiatric Units at Barnes-Jewish Hospital/Washington University in St. Louis, MO.
• Exclusion Criteria:
• • 1. Lifetime DSM-IV (obtained via MINI) diagnoses of schizophrenia, schizoaffective disorders, bipolar disorder, obsessive-compulsive disorder, evidence of severe personality disorder (e.g., history of recurrent self-mutilation/cutting, significant and recurrent tumultuous relationships), and panic disorders;
• • 2. past 12-month substance abuse/dependence other than nicotine;
• • 3. active psychotic symptoms;
• • 4. significant pulmonary disease and/or requiring supplemental oxygen;
• • 5. administration of other N-Methyl-D-aspartate (NMDA)-receptor antagonist treatment (e.g., ketamine) within two weeks of entry into study;
• • 6. currently receiving electroconvulsive therapy;
• • 7. contraindications for nitrous oxide (pneumothorax, bowel obstruction, middle ear occlusion, elevated intracranial pressure, chronic cobalamin and/or folate deficiency treated with folic acid or vitamin B12);
• • 8. past 12-month history of head trauma;
• • 9. women who are pregnant or breastfeeding;
• • 10. any other factor that in the investigators' judgment may affect patient safety or compliance.