Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

Launched by NATIONAL CANCER INSTITUTE (NCI) · Nov 13, 2018

Keywords

ClinConnect Summary

This clinical trial is studying rare solid tumors, which are types of cancer that occur in less than 15 out of every 100,000 people each year. Researchers want to learn more about how these tumors develop by collecting and analyzing biological samples, like saliva and tumor tissue, from people with these rare cancers. This could help create better ways to screen for these tumors, guide prevention, and improve treatments.

To participate, you might be eligible if you have a rare solid tumor, a family history of one, or a genetic change linked to these tumors. Participants will answer questions about their health and family history, provide samples, and may receive additional exams and tests. The study team will follow up with participants once a year to check on their health. This trial could be an important step in understanding and treating rare cancers better.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Cohort 1: Participants with a diagnosis of a rare solid tumor (fewer than 15 cases in 100,000 people per year). There are no age restrictions beyond the neonatal period (4 weeks).
• • OR
• • -Cohort 2: Participants without a rare tumor who have a germline genetic variant that predisposes to a rare solid tumor
• • OR
• • -Cohort 3: Relatives of participants with diagnosis of rare solid tumors who do NOT have a known germline variant that predisposes to a rare solid tumor
• • OR
• • Cohort 4: Parent/guardian of child participating in a focus group if not already enrolled on the study.
• • Ability of subject or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document.
• EXCLUSION CRITERIA:
• • None