Salt-Sensitivity and Immunity Cell Activation

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Nov 21, 2018

Keywords

ClinConnect Summary

This clinical trial, titled "Salt-Sensitivity and Immunity Cell Activation," is investigating how salt affects blood pressure and related health issues. It aims to understand why some people with high blood pressure, known as hypertension, are more sensitive to salt than others. The researchers believe that certain immune cells called monocytes react to salt in a way that might be connected to high blood pressure. By studying these cells, the team hopes to find a simpler method for identifying individuals who are sensitive to salt and may benefit from reducing their salt intake.

To participate in the trial, individuals must be between 18 and 60 years old and have a diagnosis of high blood pressure, which means their blood pressure readings are above 140/90 mmHg or they are taking medications for hypertension. Participants should also have a healthy weight, as defined by a Body Mass Index (BMI) of 18.5 to 24.9. The study will involve 20 participants, and those who join can expect to undergo tests that assess their body's response to salt. It’s important to note that people with certain conditions, like recent heart problems, diabetes, or pregnant women, will not be eligible to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • We will perform a pilot analysis in 20 hypertensive subjects controlled for gender (50% men, 50% women), age (18-60 years),
• • New or pre-existing diagnosis of essential hypertension defined as systolic blood pressure \>140 mmHg or \>90 mmHg diastolic or taking antihypertensive medications regardless of current blood pressure.
• • BMI (18.5-24.9).
• • Only subjects who give informed consent will be studied.
• Exclusion Criteria:
• • Acute cardiovascular event(s) within the previous 6 months
• • Claustrophobia precluding obtaining an MRI
• • Inability to understand the nature, scope, and possible consequences of the study or to participate in/comply with the protocol.
• • Current excessive alcohol or illicit drug use.
• • Blood pressure below the inclusion criteria levels after discontinuation of therapy
• • Presence of metal implants such as artificial joints.
• • Concomitant diabetes mellitus, type I or II.
• • Autoimmune disease.
• • Recent vaccination
• • Younger or older that inclusion criteria.
• • Pregnancy.