Calcium Administration in Cardiac Surgery

Launched by MESHALKIN RESEARCH INSTITUTE OF PATHOLOGY OF CIRCULATION · Dec 9, 2018

Keywords

ClinConnect Summary

This clinical trial is studying the effects of calcium administration during cardiac surgery, specifically when patients are being taken off a machine called cardiopulmonary bypass (CPB). This machine helps keep blood flowing and oxygenated during surgery on the heart. The researchers want to find out if giving calcium at this crucial time can help reduce the need for additional medications to support the heart after surgery. This is important because both low and high levels of calcium can cause serious complications, including heart rhythm problems.

To be eligible for this study, participants must be adults over 18 years old who are undergoing surgery that requires cardiopulmonary bypass, such as valve surgery or coronary artery bypass grafting (CABG). Those with certain medical conditions or who are undergoing emergency surgery will not be included. If you decide to participate, you will receive either calcium or a placebo (a substance with no active ingredient) during your procedure, and your progress will be monitored closely by the medical team. This trial is currently looking for volunteers, and your involvement could help improve future care for patients undergoing heart surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • surgery under cardiopulmonary bypass
• • valve or valve surgery + CABG
• • age \> 18 years
• • signed informed consent
• Exclusion Criteria:
• • emergency surgery
• • isolated aortic valve repair/replacement
• • planned (before surgery) blood transfusion
• • redo surgery
• • known allergy to the study drug
• • pregnancy
• • current enrollment into another RCT (in the last 30 days)
• • previous enrollment and randomization to ICARUS trial
• • liver cirrhosis (Child B or C)
• • transfusion during CPB
• • hypo- or hyperparathyreosis