Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function

Launched by UNIVERSITY OF ZURICH · Dec 17, 2018

Keywords

ClinConnect Summary

This clinical trial is studying how different pain relief medications, specifically Tramadol, Paracetamol, and Diclofenac, affect the body’s sympathetic nervous system and blood circulation in people with osteoarthritis in their ankles or feet, as well as in healthy individuals. The researchers want to see how these medications influence things like blood pressure and heart rate, which are important for overall health.

To participate, you need to be at least 18 years old, either with a diagnosis of osteoarthritis or healthy. You’ll be asked to provide written consent to join the study. However, some people may not be eligible, including those with certain heart conditions, allergies to the study medications, or those who are pregnant or breastfeeding. If you join, you can expect to undergo tests that will help researchers learn more about how these medications work in the body. This trial is currently looking for participants, so it’s a great opportunity to contribute to important medical research.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Patients ≥ 18 years of age, male or female, with a diagnosis of osteoarthritis or healthy subjects ≥ 18 years of age;
• • 2. Written informed consent;
• Exclusion criteria:
• • 1. History of hypersensitivity or allergy to any of the study drugs
• • 2. Acute coronary syndrome, stroke, transient ischemic attack, cardiac, carotid or other major CV surgery, percutaneous coronary intervention (PCI) or carotid angioplasty within the 3 months prior to Visit 1;
• • 3. Coronary or carotid artery disease likely to require surgical or percutaneous intervention within the 3 months after Visit 1;
• • 4. Presence of significant endocrine diseases;
• • 5. Presence of active acute infectious diseases;
• • 6. Known narrow-angle glaucoma;
• • 7. Known epilepsy;
• • 8. Cimino-shunt operation on both arms;
• • 9. Pregnancy, intention thereof during study, lack of sufficient contraception, breastfeeding;
• • 10. Drug or alcohol abuse;