Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
Launched by MIRATI THERAPEUTICS INC. · Dec 19, 2018
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The KRYSTAL-1 clinical trial is studying a new drug called MRTX849 (also known as adagrasib) in patients with advanced cancer that has a specific genetic change known as the KRAS G12C mutation. This trial aims to find out how safe the drug is, how well it works, and how it affects the body at different levels. If you have a solid tumor that cannot be surgically removed or has spread to other parts of the body, and previous standard treatments are not an option for you, you may be eligible to participate.
To join the study, participants need to have a confirmed diagnosis of cancer with the KRAS G12C mutation and must be 65 years or older. They should also have good organ function and not have other active cancers or certain gastrointestinal issues that would prevent them from taking oral medications. If you decide to participate, you will be closely monitored throughout the trial to assess how the drug affects your condition and overall health. This research could help develop new treatment options for patients with this specific type of cancer.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12C mutation
- • Unresectable or metastatic disease
- • Standard treatment is not available or patient declines; first-line treatment for NSCLC for certain cohorts
- • Adequate organ function
- Exclusion Criteria:
- • History of intestinal disease or major gastric surgery or inability to swallow oral medications
- • Other active cancer
About Mirati Therapeutics Inc.
Mirati Therapeutics, Inc. is a biopharmaceutical company dedicated to discovering and developing transformative therapies for patients with genetically defined cancers. With a strong focus on precision medicine, Mirati leverages advanced science and innovative technologies to identify and target specific genetic mutations driving cancer progression. The company’s robust pipeline includes novel small molecules and immunotherapies, aimed at addressing significant unmet medical needs and improving patient outcomes. Committed to advancing oncology research, Mirati collaborates with healthcare professionals and research institutions to bring cutting-edge treatments from the lab to the clinic.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Minneapolis, Minnesota, United States
Orange, California, United States
Boston, Massachusetts, United States
Orange, California, United States
Lexington, Kentucky, United States
Charleston, South Carolina, United States
Iowa City, Iowa, United States
Seattle, Washington, United States
Jacksonville, Florida, United States
Detroit, Michigan, United States
New York, New York, United States
Miami Beach, Florida, United States
Seattle, Washington, United States
Boston, Massachusetts, United States
Duarte, California, United States
Boston, Massachusetts, United States
Detroit, Michigan, United States
Birmingham, Alabama, United States
Aurora, Colorado, United States
Omaha, Nebraska, United States
Jacksonville, Florida, United States
Iowa City, Iowa, United States
Omaha, Nebraska, United States
Cincinnati, Ohio, United States
Miami, Florida, United States
Madison, Wisconsin, United States
Fullerton, California, United States
Houston, Texas, United States
Chapel Hill, North Carolina, United States
Chapel Hill, North Carolina, United States
Bend, Oregon, United States
Richmond, Virginia, United States
Newport Beach, California, United States
Jefferson City, Missouri, United States
Fort Worth, Texas, United States
Anchorage, Alaska, United States
Aurora, Colorado, United States
Cincinnati, Ohio, United States
Houston, Texas, United States
Rochester, Minnesota, United States
Westwood, Kansas, United States
Cleveland, Ohio, United States
Bolivar, Missouri, United States
Marietta, Georgia, United States
Columbus, Ohio, United States
Minneapolis, Minnesota, United States
Vallejo, California, United States
San Antonio, Texas, United States
Buffalo, New York, United States
Las Vegas, Nevada, United States
Tucson, Arizona, United States
Columbus, Ohio, United States
South Bend, Indiana, United States
South Bend, Indiana, United States
Ocala, Florida, United States
Tyler, Texas, United States
La Jolla, California, United States
Beverly Hills, California, United States
New Haven, Connecticut, United States
Sugar Land, Texas, United States
Pensacola, Florida, United States
Fairfax, Virginia, United States
Waco, Texas, United States
Omaha, Nebraska, United States
Boca Raton, Florida, United States
Rochester, Minnesota, United States
Phoenix, Arizona, United States
Fredericksburg, Virginia, United States
New York, New York, United States
Buffalo, New York, United States
New Haven, Connecticut, United States
Athens, Georgia, United States
Pinehurst, North Carolina, United States
Newark, Delaware, United States
Hershey, Pennsylvania, United States
Plantation, Florida, United States
Saint Louis Park, Minnesota, United States
Vallejo, California, United States
Kettering, Ohio, United States
San Antonio, Texas, United States
Buffalo, New York, United States
Niles, Illinois, United States
Madison, Wisconsin, United States
Albany, New York, United States
Saint Louis Park, Minnesota, United States
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Cleveland, Ohio, United States
Bellflower, California, United States
San Diego, California, United States
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Grand Junction, Colorado, United States
Miami, Florida, United States
Orange City, Florida, United States
Biddeford, Maine, United States
Columbia, Maryland, United States
Detroit, Michigan, United States
Minneapolis, Minnesota, United States
Jefferson City, Missouri, United States
Billings, Montana, United States
Cincinnati, Ohio, United States
Eugene, Oregon, United States
Allentown, Pennsylvania, United States
Charleston, South Carolina, United States
Nashville, Tennessee, United States
Arlington, Texas, United States
Austin, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Sugar Land, Texas, United States
Waco, Texas, United States
Newport News, Virginia, United States
Vancouver, Washington, United States
San Juan, , Puerto Rico
Dallas, Texas, United States
Chicago Ridge, Illinois, United States
Ocala, Florida, United States
Los Alamitos, California, United States
Hershey, Pennsylvania, United States
Houston, Texas, United States
Fairfax, Virginia, United States
Baton Rouge, Louisiana, United States
Kingwood, Texas, United States
Fort Myers, Florida, United States
Saint Petersburg, Florida, United States
West Palm Beach, Florida, United States
New York, New York, United States
Fort Myers, Florida, United States
Saint Petersburg, Florida, United States
West Palm Beach, Florida, United States
Chicago Ridge, Illinois, United States
Columbus, Ohio, United States
Lawton, Oklahoma, United States
Midland, Texas, United States
Richmond, Virginia, United States
Vancouver, Washington, United States
Niles, Illinois, United States
Biddeford, Maine, United States
Columbia, Maryland, United States
Nashville, Tennessee, United States
Tulsa, Oklahoma, United States
Media, Pennsylvania, United States
Dallas, Texas, United States
Athens, Georgia, United States
New York, New York, United States
Duarte, California, United States
Fullerton, California, United States
Birmingham, Alabama, United States
Phoenix, Arizona, United States
Scottsdale, Arizona, United States
Tucson, Arizona, United States
Los Alamitos, California, United States
Los Angeles, California, United States
Newport Beach, California, United States
San Diego, California, United States
Aurora, Colorado, United States
Aurora, Colorado, United States
Grand Junction, Colorado, United States
Lafayette, Colorado, United States
Newark, Delaware, United States
Orange City, Florida, United States
Marietta, Georgia, United States
Chicago Ridge, Illinois, United States
Chicago, Illinois, United States
Iowa City, Iowa, United States
Baton Rouge, Louisiana, United States
Minneapolis, Minnesota, United States
Billings, Montana, United States
Henderson, Nevada, United States
Lake Success, New York, United States
New York, New York, United States
Cincinnati, Ohio, United States
Kettering, Ohio, United States
Oklahoma City, Oklahoma, United States
Tulsa, Oklahoma, United States
Allentown, Pennsylvania, United States
Media, Pennsylvania, United States
Charleston, South Carolina, United States
Arlington, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Denison, Texas, United States
Fort Worth, Texas, United States
Irving, Texas, United States
Midland, Texas, United States
Tyler, Texas, United States
Fairfax, Virginia, United States
Fredericksburg, Virginia, United States
Newport News, Virginia, United States
San Juan, , Puerto Rico
Tucson, Arizona, United States
Bellflower, California, United States
Dublin, California, United States
Harbor City, California, United States
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Austell, Georgia, United States
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Brandywine, Maryland, United States
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Maplewood, Minnesota, United States
Maplewood, Minnesota, United States
Minneapolis, Minnesota, United States
Minneapolis, Minnesota, United States
Minneapolis, Minnesota, United States
Saint Louis Park, Minnesota, United States
Saint Paul, Minnesota, United States
Saint Paul, Minnesota, United States
Woodbury, Minnesota, United States
Omaha, Nebraska, United States
Omaha, Nebraska, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Columbus, Ohio, United States
Gahanna, Ohio, United States
Kettering, Ohio, United States
Tulsa, Oklahoma, United States
Bend, Oregon, United States
Bethlehem, Pennsylvania, United States
Gallatin, Tennessee, United States
Hendersonville, Tennessee, United States
Hermitage, Tennessee, United States
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Nashville, Tennessee, United States
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Arlington, Texas, United States
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Kingwood, Texas, United States
Shenandoah, Texas, United States
Spring, Texas, United States
Tomball, Texas, United States
Norfolk, Virginia, United States
Colorado Springs, Colorado, United States
Bonita Springs, Florida, United States
Bradenton, Florida, United States
Cape Coral, Florida, United States
Fort Myers, Florida, United States
Fort Myers, Florida, United States
Naples, Florida, United States
Naples, Florida, United States
Port Charlotte, Florida, United States
Sarasota, Florida, United States
Sarasota, Florida, United States
Venice, Florida, United States
Venice, Florida, United States
Norfolk, Virginia, United States
Patients applied
Trial Officials
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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