Ischemic Postconditioning in STEMI Patients Treated With Primary PCI

Launched by RIGSHOSPITALET, DENMARK · Dec 21, 2018

Keywords

ClinConnect Summary

The iPOST2 clinical trial is studying a technique called ischemic postconditioning to see if it can help reduce damage to the heart after a serious heart attack known as STEMI (ST Segment Elevation Myocardial Infarction). This technique may improve recovery and reduce the chances of heart failure or death for patients who are treated with a procedure called primary PCI (Percutaneous Coronary Intervention). The trial is currently looking for participants, and you may be eligible if you are at least 18 years old, have experienced chest pain for less than 12 hours, and have specific heart-related indicators that suggest you are having a STEMI.

If you join the trial, you will receive care related to both your heart attack and the study treatment. This is an important opportunity to help researchers learn more about how to improve outcomes for people who have had a heart attack. It's important to note that certain individuals may not be eligible, such as those who are pregnant or have had a cardiac arrest without regaining consciousness. By participating, you could contribute to advancements in heart attack treatment for others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years
• • Acute onset of chest pain with \< 12 hours duration
• • STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI.
• • TIMI flow 0-1 in infarct related artery
• Exclusion Criteria:
• • Potential pregnancy
• • Refusal to participate
• • OHCA without subsequent consciousness despite ROSC
• • Thrombectomy considered unavoidable