Cardiac Dysfunction in Childhood Cancer Survivors

Launched by UNIVERSITY OF BERN · Dec 29, 2018

Keywords

ClinConnect Summary

This clinical trial is studying the heart health of adult survivors who were treated for childhood cancer. Researchers want to find out if a newer heart imaging technique called speckle tracking echocardiography can detect heart problems earlier than the traditional method. This is important because many childhood cancer survivors may face heart issues later in life, and catching these problems early could help with better management and treatment.

To participate in this study, individuals must have been diagnosed with cancer before the age of 20 and survived at least five years after their treatment. They should have received chemotherapy or chest radiation and be at least 18 years old. Participants will undergo heart tests to assess their heart function. The study is currently recruiting participants across Switzerland, and anyone interested will need to provide written consent to join. This research aims to improve the care of childhood cancer survivors by identifying heart issues sooner.

Gender

ALL

Eligibility criteria

• • This prospective cohort study is nested within the Childhood Cancer Registry (ChCR), a national, population-based cancer registry that includes all children and adolescents in Switzerland who were diagnosed with cancer at age 0-20 years. It includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumours or Langerhans cell histiocytosis. Childhood cancer survivors have survived at least 5 years from cancer diagnosis.
• Inclusion Criteria:
• • Registered in the ChCR
• • Formerly treated at the Department of Pediatric Hematology/Oncology of one of five participating centers
• • Treated with any chemotherapy and/or chest radiation
• • Survived ≥ 5 years since most recent cancer diagnosis (primary cancer, relapse(s), secondary cancer) at time of examination
• • Diagnosed at age ≤ 20 years
• • ≥ 18 years of age at time of study participation
• • Resident in Switzerland
• • Written informed consent
• Exclusion Criteria:
• • Study participants will be excluded if they do not meet the above mentioned inclusion criteria or refuse to participate in the study.