The BRIDGE Study - Bronchiectasis Research Involving Databases, Genomics and Endotyping

Launched by UNIVERSITY OF DUNDEE · Dec 29, 2018

Keywords

ClinConnect Summary

The BRIDGE Study is a research project focused on understanding bronchiectasis, a condition where the airways in the lungs become damaged and enlarged, making it hard to breathe. This study aims to identify different types of bronchiectasis by looking at patients' genetic and biological profiles. By doing so, the researchers hope to develop personalized treatment strategies that can help patients respond better to their care. The study will gather information about patients when they are stable and during flare-ups, which will help link specific patient characteristics to health outcomes.

To participate in this study, individuals must be adults aged 18 and older with a confirmed diagnosis of bronchiectasis, supported by a CT scan. Participants should have been stable for at least four weeks without needing antibiotics or steroids for their condition. Those who are eligible will be closely monitored and asked to provide information about their health, which will help researchers gain insights into the best ways to treat bronchiectasis in different patient groups. This study is currently recruiting participants, and both men and women are welcome to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • A previous CT scan showing bronchiectasis along with compatible clinical syndrome of cough, sputum production and/or recurrent respiratory tract infections.
• • A primary diagnosis of bronchiectasis made by a respiratory physician
• • At the screening visit the individual will have been clinically stable for 4 weeks indicated by the lack of any treatment with antibiotics or corticosteroids for a pulmonary exacerbation in the previous 4 weeks.
• Exclusion Criteria:
• • Inability to give informed consent
• • \<18years of age
• • Patients with active tuberculosis
• • Treatment with antibiotics or corticosteroids for a pulmonary exacerbation in the previous 4 weeks
• • Bronchiectasis due to cystic fibrosis