Genetic and Epigenetic Basis of Chronic Wounds

Launched by UNIVERSITY OF PITTSBURGH · Jan 3, 2019

Keywords

ClinConnect Summary

This clinical trial is looking at the reasons why some chronic wounds—those that don’t heal as they should—don’t improve over time. The researchers believe that these wounds have specific genetic features that can be identified by examining tissue that is removed during standard wound care. By comparing the genetic information from the wound tissue with samples taken from the blood, the study aims to uncover clues about why these wounds struggle to heal.

To participate in this study, you need to be at least 18 years old and have a chronic wound that has been present for more than four weeks, which could be a diabetic or non-diabetic ulcer. If you have multiple wounds, the largest one will be the focus of the study. It’s important to know that you should be able to understand the study details and provide consent, and pregnant or breastfeeding individuals are not eligible. If you decide to take part, you'll attend study visits where your wound and health will be monitored, helping researchers learn more about chronic wounds and how to treat them better.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Willing to comply with protocol instructions, including all study visits and study activities.
• • Chronic wounds (\> than four weeks since onset)
• • Clinically diagnosed diabetic or non-diabetic ulcer.
• • For patients with multiple wounds, the largest wound will be used for the study.
• Exclusion Criteria:
• • Individuals who are deemed unable to understand the procedures, risks and benefits of the study,(i.e. unable to provide informed consent)
• • Pregnant females (self-declared) or lactating
• • Subjects with marked immunodeficiency (HIV/AIDS or immune-suppressive medications)
• • Prisoners