Efficacy of Intrabronchial Voriconazole Instillation for Inoperable Pulmonary Aspergilloma

Launched by ALL INDIA INSTITUTE OF MEDICAL SCIENCES · Jan 9, 2019

Keywords

ClinConnect Summary

Primary Objective : To compare the percentage of patients achieving reduction in hemoptysis in intrabronchial voriconazole with standard medical therapy group vs standard medical therapy alone for inoperable symptomatic pulmonary aspergilloma.

Secondary Objectives:

1. To compare the percentage of patients who have complete cessation of hemoptysis after 3 months.
2. To compare the percentage of patients having recurrence of hemoptysis during 3 months follow up.
3. To compare the severity of hemoptysis during recurrence in both groups.
4. To compare the change in size of aspergilloma after ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with mild to moderate hemoptysis AND inoperable aspergilloma/ those unwilling for surgery.
• • Who have no contra-indication of flexible fibre-optic bronchoscopy
• • Age \> 18 yrs AND
• • Given the written informed consent to participate in the study.
• Exclusion Criteria:
• • Patient who are not fit for FOB (e.g. hemodynamic instability)
• • Patient who have life threatening hemoptysis requiring immediate bronchial artery embolization
• • Patients who have underwent BAE in last 3 months
• • Pregnant woman