Skeletal Muscle Function in Interstitial Lung Disease

Launched by UNIVERSITY OF BRITISH COLUMBIA · Jan 9, 2019

Keywords

ClinConnect Summary

This clinical trial is studying how muscle function affects breathing and exercise in people with interstitial lung disease (ILD), which includes conditions like idiopathic pulmonary fibrosis and hypersensitivity pneumonitis. Researchers want to find out if problems with leg muscles contribute to feelings of breathlessness and difficulty exercising. They will also explore whether breathing extra oxygen can help reduce muscle fatigue and improve exercise abilities in these patients.

To participate, you should be between 40 and 80 years old and have a confirmed diagnosis of one of the specified ILD conditions. You must also be able to walk a certain distance and have stable health for the past six weeks. If you qualify, you will undergo tests to measure your muscle strength and how well you can exercise, along with other assessments. This study aims to improve understanding of the challenges faced by ILD patients, potentially leading to better treatments and support for those living with this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for ILD Patients:
• • Age 40-80 years (inclusive)
• • A multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF), idiopathic fibrotic nonspecific interstitial pneumonia (NSIP), chronic hypersensitivity pneumonitis (HP), or unclassifiable ILD with a differential diagnosis that consists of the above diagnoses
• • Fibrosis on high resolution computed tomography (HRCT): honeycombing, reticulation, or traction bronchiectasis
• • Appropriate candidate for pulmonary rehabilitation
• • 6 minute walk distance 50m or more
• • Oxygen saturation ≥ 92% by pulse oximetry at rest while breathing room air
• • Clinically stable for the preceding 6 weeks
• • Can fluently read and write in English
• Inclusion Criteria for Healthy Controls:
• • Age 40-80 (inclusive)
• • Normal pulmonary function (80-120% predicted)
• • No lung or cardiovascular disease
• • Can fluently read and write in English
• Exclusion Criteria for the ILD patients:
• • Contraindication to exercise testing (e.g. significant cardiovascular, musculoskeletal, neurological disease)
• • Other significant extra-pulmonary disease that, based on clinical assessment, could impair exercise capacity and/or oxygenation
• • Forced vital capacity (FVC) less than 50% or Diffusion capacity for carbon monoxide (DLCO) less than 25%
• • Concurrent or recent participation (less than 6 months) in a pulmonary rehabilitation program
• • Use of prednisone greater than 10 mg/day for more than 2 weeks within 3 months of the first study visit
• • Significant emphysema (less than 10% volume on HRCT or FEV1/FVC less than 0.70)
• Exclusion Criteria for Healthy Controls:
• • Currently smoking or previously smoked more than 10 pack-years
• • Any medical conditions that prevents them for exercising safely
• • Cardiac pacemaker or any metal or electronic inside the body